本研究以電化學阻抗分析方式量測鹽酸左旋布比卡因(levobupivacainehydrochloride)的濃度，並可偵測至 1 ppm。本文以電聚合方式，將吭咯(pyrrole)聚合成的感測材料聚吭咯(polypyrrole， Ppy)薄膜鍍製於金電極上，聚合完成的Ppy薄膜再經過循環伏安儀來作定性分析。使用分子視算軟體MaterialStudio software 4.0 '計算左旋布比卡因吸附於感測材料3x 3 Ppy表面，其吸附能量下降約1.88 kcal/mol及最近距離約在0.24 至0.26nm附近。在樣品感測上，除了使用去離子水作為溶劑之外，也使用醫療中常使用的注射液0.9% 生理食鹽水注射液作為溶劑，左旋布比卡因濃度於1至10000ppm之間變化。使用10 kHz頻率來繪製實 阻抗對濃度變化的檢量線，檢量線之線性相關係數R-squ征e在純水系統下為0.994。而針對各種不同的電化學參數，可以利用所提出相對應的模型來推算等效電路。

An electrochemical impedance method to detect concentrations of the local anesthetics levobupivacaine was implemented and the concentration could be detected to 1 ppm. Electropolymerized pyrrole to polypyrrole (Ppy) was fabricated on gold electrodes and used as sensors. Cyclic voltammeter (CV) was applied to the characterization of the sensing material Ppy.Material Studio software 4.0 was used to simulate the Levobupivacaine molecule on the surface of the 3 x 3 Ppy， and the adsorption energy was calculated as -1.88kcal/mol. The nearest distance between the Levobupivacaine and Ppyis around 0.24 to 0.26 nm. Various concentrations of rocuronium from 1 to 10,000ppm were prepared in DI water and medical injection 0.9% NaCI solution as the test samples. A 10 kHz frequency was used in the analytical curve， and the R-square value was 0.994 in DI water system. Equivalent circuits in the electrochemical system were determined in this study.