背景:目前已有許多研究證實牙周病是糖尿病患血糖控制差的危險因子，而糖尿病也是牙周病惡化的原因之一，營養素攝取可能同時或分別為牙周疾病和糖尿病的相關因子，但是營養素攝取與糖尿病患牙周狀態之間關係的議題卻很少被談論。
研究目的:探討營養素攝取與糖尿病患牙周狀態之間的相關性。
材料與方法:自2006年8月至2007年4月為止，在高雄醫學大學附設中和紀念醫院新陳代謝科收集211位糖尿病患，收集飲食問卷(巨量，微量)，臨床血液生化值糖化血色素(glycosylatedhemoglobin AIC，簡稱HbAIC)及 空腹血糖。進行口腔檢查以社區牙周指數CommunityPeriodontal Index (CPI)表示，同時將CPI三至2羊毛牙周良好 組，CPI這3為牙周不良組。臨床血液生化值之HbAIC (本研究HbAIC變項資料，中位數為7.6%'所以將HbAIC三五7.5%定義為血糖控制良好組，將HbAIC>7.5% 定義為血糖控制不良組)。
結果:研究發現糖尿病患牙周不良組中有54.6%的人HbAIC> 7.5% '顯著的高於牙周良好組的35.9%(p=0.0403)。在所研究之營養素，只有維生素E攝取量 (mgα-生育醇當量(α-Tocopherol Equivalent ;α-TE)在 牙周良好組5.8士3.3mg/d呵，顯著高於不良組的 4.6士3.lmg/day (p=0.0329)。在調整性別、年齡、教育程 度、身體質量指數及熱量後，分析維生素E攝取量分組( >75百分位，比三75百分位)與CPI的 、目關，發現每日維生素E攝取量>75百分立組，與CPI呈現顯著性負相關p=0.0410)。
結論:牙周不良組中HbAIC>7.5%的固案數較多(p=0.0403)，維生素E在牙周良好組攝取量顯著高於牙周不良組，即使在調整性別、年齡、教育程度、身體質量指數、熱量後，仍達統計上顯著差異，顯示維生素E攝取量與牙周狀況具顯著性負相關性。未來的研究可考慮探討它的生物機轉。

Background :
Scientific evidence has reported severe periodontosis is a risk factor for poor glucemic control and studies have shown that diabetes mellitus is the main reason for the worsening of periodonta disease. Nutrient intake may be one of the important factors affecting periodontal disease an( diabetes mellitus; however， the relationship between nutrient intake， biochemical examination， an( periodontal disease has rarely been discussed.
Objective:
The objective of this investigation was to examine the relationship between nutrient intake aw periodontal status in type 2 diabetes mellitus.
Material and Methods :
211 patients with type 2 diabetes mellitus were recruited from the Department of Endocrinolog:
in Kaohsiung Medical University Hospital from April to August， 2006. Periodontal status wa evaluated by the Community Periodontal Index (CPI). Subjects were divided into two group5 according to CPI index; patients whose CPI<=2 is in the Periodontal-well -status group， ani patients whose CPI>=3 is in the Periodontal-bad-status group. The nutritional intake status wa evaluated by a 24-hour diet record.
Results:
Distribution of subjeuts with A1C > 7.5% was significautly higher in CPI>=3 group thai CPI<= 2 group. The Periodontal-well-status group had higher vitamin E 5.8土 3.3 mg/da:
(α- Tocopherol Equivalent ;α- TE) intake compared with the CPI>=3 group 4.6士3.1mg/da: (p=0.0329). Using multiple linear regression analysis to adjust for sex， age， education， body mas index and kilocalorie， Vitamin E intake was negativey related to CPI status (/3=-0.4， p=0.0410; Conclusion:
Periodontal status was related to long“term blood glucose control in diabetes patients. UpOI adjustment for confounders， Vitamine E intake amount was related to periodontal status. Furthe study should be undertaken to examine the underlying mechanism.