背景：運動對臺灣中年婦女具心血管疾病危險因子之成效仍不清楚。方法：本研究共36位年齡在35-64歲且至少有一項心血管疾病危險因子之婦女，參與為期八週之研究計劃，研究對象被平均分配至運動組及對照組，運動組參與每週三次、每次三十分鐘之跑步機訓練，對照組則維持其日常生活，兩組在研究計劃前及完成研究計劃後，均抽血檢查血液生化值、血壓及身體組成測量、填寫情緒狀態量表。結果：運動組在八週運動訓練後，其身體質量指數 (p = 0.01)、腰臀圍比 (p = 0.04)、收縮壓 (p = 0.01)、舒張壓 (p < 0.001) 均有顯著降低，同時情緒狀態 (p < 0.01) 亦有明顯之改善。而兩組在研究計劃前後之腰臀圍比 (p = 0.03) 及情緒狀態 (p = 0.04) 則有顯著之差異。同時以複迴歸檢視發現在調整年齡、停經狀態及使用荷爾蒙後，並不會影響運動訓練對腰臀圍比 (β = -0.43, p = 0.02) 及情緒狀態 (β = -0.37, p = 0.04) 的結果。結論：八週之運動訓練能夠降低國內具心血管疾病危險因子婦女之腰臀圍比血壓及改善情緒狀態。

Background: The effects of exercise on cardiovascular disease risk factors among middle-aged women at risk of the disease in Taiwan remained unclear.Methods: Thirty-six women (35-64 years) with more than 1 traditional cardiovascular risk factor were equally assigned into the exercise group (with a treadmill training program for 30 minutes each time, 3 times a week for 8 weeks, n = 18) and a control group (maintained their previous lifestyles, n = 18). Blood biochemistries, resting blood pressure, body composition, and mood state were evaluated before and after the 8-week period.Results: Compared with the baseline, the exercise group had significantly lower body mass index (p = 0.01), waist-to-hip ratio (p = 0.04), and systolic (p = 0.01) and diastolic (p ＜ 0.001) blood pressure, as well as a better mood state (p ＜ 0.01) after 8 weeks of exercise. However, the control group did not have significant changes in the parameters. Comparison between the groups showed that the exercise group had significant changes in waist-to-hip ratio (p = 0.03) and mood state (p = 0.04). Using multivariable linear regression model, we demonstrated that exercise was significantly related to waist to hip ratio (β= -0.43, p = 0.02) and total mood scores (β = -0.37, p = 0.04) after adjustment for age, menopause, and previous hormone replacement therapy.Conclusion: A simple 8-week exercise program is able to effectively modify cardiovascular risk factors, such as the waist-to-hip ratio, blood pressure, and the mood state in Taiwanese women at risk of the disease.