To cope with the challenges of Taiwan's healthcare system, the Department of Health (DOH) has proposed a five-year National Healthcare Information Project (NHIP) to establish a nationwide infrastructure for electronic health record (EHR) and health information exchange. An interoperable EHR adoption project, as part of NHIP, setup among eleven medical centers in 2007. We conduct a study to assess the major issues and challenges of EHR adoption in Taiwan and use a qualitative approach to solicit stakeholder opinions from pertinent hospital staff, experts, vendors and consumers. Several suggestions are made for stakeholders that may adopt EHR and for policymakers to set related strategies and policies. These suggestions include enhancing the patient information transparency, strengthening privacy and data protection, accelerating system interoperability and standard adoption, and creating financial incentives for EHR adoption. Our study suggests that EHR may be widely used as an alternative tool for DOH to improve continuity of patient care and furthermore enhance cost containment in healthcare.