本研究首先利用白肉雞與烏骨雞屠宰場之廢棄物-雞血為原料，分別使用冷凍乾燥與熱風乾燥 (50℃) 製成血粉樣品，分析血粉之胜肽含量與血管收縮素I轉換酶 (Angiotensin I converting enzyme, ACE) 抑制活性，結果顯示烏骨雞血粉之胜肽含量顯著高於白肉雞血粉 (p < 0.05)，且又以冷凍乾燥方式含有較高之胜肽含量 (p < 0.05)。In vitro ACE抑制活性方面，以烏骨雞冷凍乾燥的處理組 (SBL) 有最佳的抑制活性 (38.91%)，白肉雞熱風乾燥的血粉抑制活性最低 (5.11%)。因此選取冷凍乾燥之烏骨雞血粉進行原發性高血壓鼠 (Spontaneously Hypertension Rat, SHR) 的餵食，以探討其抗高血壓效果。結果發現，將100 mg/kg bw之冷凍乾燥烏骨雞血粉餵予原發性高血壓鼠可以在第四小時顯著降低其血壓達25-30 mmhg (p < 0.05)；經長期餵予八週後，發現SHR之高血壓症狀有顯著改善。另外將相同劑量 (100 mg/kg bw/day) 血粉餵予WKY (Wistar-Kyoto) 正常鼠後發現，並不會影響WKY之血壓。本研究之結果顯示烏骨雞冷凍乾燥血粉有開發為抗高血壓機能性健康食品之潛力。

Lyophilization and hot-air drying methods were applied to utilize broiler and silkie fowl blood, which were by-products from slaughter houses, as blood meal samples. Peptide content and ACE inhibitory activity of broiler and silkie fowl blood meal were investigated. Results showed that the silkie fowl blood meal had signifcantly higher peptide contents than broiler meal (p < 0.05), and the lyophilization method was contributed to higher peptide contents in blood meal (p < 0.05). In ACE inhibitory activity, the silkie fowl blood meal obtained from lyophilization method (SBL) showed the best inhibitory activity (38.91%) and the broiler blood meal obtained from hot-air drying method was poor (5.11%). According to the results, SBL was applied to determined the antihypertensive activity in animal model (SHR). The result showed that a signifcant reduction (25-30 mmHg) was observed in systolic blood pressure of SHRs after orally administrated for 4 hours. The chronic experiment also indicated oral administration of SBL (100 mg/kg bw/day) for 8 weeks improved symptom of hypertension in SHRs. Moreover, SBL did not infuence blood pressure of normotension rats (WKY) in the same dose (100 mg/kg bw/day). These results suggested that lyophilized silkie fowl blood meal had high potential to be eveloped as the functional food with antihypertensive activity.