尿酸除了大家所熟知地會導致痛風外，近來的研究顯示它同時也與高血壓、糖尿病、腎臟病與心血管疾病相關。而針對尿酸與腎臟病的研究指出，在腎功能正常的族群中，尿酸與之後發生慢性腎臟病與進入透析的機率增加有關。但在已存在慢性腎臟病的族群，尿酸是否會加速腎功能的惡化，尚待進一步的研究報告。本文就尿酸的代謝、生物特性、動物實驗及流行病學，來探討尿酸與腎臟病之間的相關性。

Uric acid is well-known for its causality of gout. Recent researches also show it relates to hypertension, diabetes mellitus, renal disease and cardiovascular disease. Studies focused on uric acid and renal isease point out that uric acid does increase risk of chronic kidney disease and end stage renal disease in general population. However, in CKD group, it needs further report to see if uric acid deteriorates renal function. This article explores relation between uric acid and renal disease in view of its metabolism, biologic characters, animal studies and epidemiology.