基因研究、癌症診療及發展生物學是目前生醫科技領域極重要之研究課題，微循環血流的改變量在癌症及糖尿病治療過程當中是一項相當重要的指標。現有之超音波醫學影像技術大多應用於較大組織與器官，觀察其型態與血流動態的資訊，為了使之能有效運用在人體微循環血流之量測，高解析度超音波影像系統是一項重要的技術發展。高解析度超音波已經發展用於非侵入式觀察體表微細組織，例如皮膚、眼睛的前腔室及小老鼠胚胎影像等。最近許多研究，高頻超音波影像系統可用於彩色都卜勒及功率都卜勒影像模式上，計算出微循環血流速度及功率都卜勒的分布，此外，配合超音波微氣泡對比劑可增強影像系統靈敏度，進而發展超音波分子影像系統平台。由於高頻超音波影像穿透深度受到限制，因此未來高頻超音波影像系統主要應用於小動物腫瘤新生血管觀察與臨床表淺血流評估。

The studies of gene research, cancer therapy and developmental biology have become very important issues in the field of bio-technology. Microcirculation changes occur in many disease states including cancer and diabetes and it is an important index in clinical diagnosis. The main goal of the report is to develop novel ultrasound imaging technologies and apply them to estimate microcirculation. High frequency ultrasound system has been developed for noninvasive imaging of microcirculation such as the skin, the anterior chamber of the, and mouse embryos. More recent improvements include color Doppler and power Doppler imaging modes which allow mapping of blood velocity and power, respectively. At the same time, ultrasound imaging technology has progressed with the development of ultrasound microbubbles contrast agents and with improvements in spatial resolution and dynamic rang. Potential applications of the high-resolution ultrasound imaging include the high-resolution assessment of tumor volumetric blood flow in small animals and the evaluation of the superficial vasculature in clinical studies.