嚼檳榔是台灣地區口腔癌的主要危險因子,嚼檳榔也與肝硬化、肝癌、心血管疾病、代謝症候群相關。根據調查,台灣社區脂肪肝盛行率大約30~50%,但嚼檳榔是否與脂肪肝有關,目前仍不清楚,本研究以2006至2008年,桃園縣一所優等區域教學醫院接受年度健康檢查之職場男性員工(健檢項目包含腹部超音波查檢查者)為研究對象,探討非酒精性脂肪肝的危險因子,並分析嚼檳榔與罹患非酒精性脂肪肝的關係。
本研究共納入3118名男性為有效樣本。其中非酒精性脂肪肝有1565人(50.2%),嚼檳榔有343人(11.0%)。經多變項羅吉斯迴歸分析發現:非酒精性脂肪肝盛行的危險因子有高年齡層、體重過重、肥胖、糖尿病、高膽固醇、高三酸甘油酯、肝功能(ALT)異常及高尿酸。嚼檳榔與罹患非酒精性脂肪肝並無顯著相關。在此次研究樣本中,非酒精性脂肪肝的盛行率高達50.2%。這顯示非酒精性脂肪肝是職業醫學上值得持續關注的健康問題。
Chewing betel nut is the main risk factor of oral cancer, and is related to liver cirrhosis, hepatocellular carcinoma, cardiovascular diseases, and metabolic syndrome in Taiwan. Not only high hepatitis B infection prevalence and high hepatocellular carcinoma mortality, but also 30%~50% high prevalence of non-alcoholic fatty liver were found in Taiwan. The relationship between betel nut use and non-alcoholic fatty liver remains unclear. In this study we recruit male workers who received health checkups, including abdominal echo examination and labo-ratory test, at Landseed hospital,Taoyuan, Taiwan, in 2006 to 2008.We investigate the risk factors of non-alcoholic fatty liver among workers in Taiwan, especially the use of betel nut.
Among 3118 male workers, 1565 (50.2%) was non-alcoholic fatty liver case, 343 (11.0%) workers chewed betel nut. After performing multiple logistic regression modeling, the risk fac-tors associated with the non-alcoholic fatty liver were age, over-weight, obesity, diabetes, hy-
percholesterolemia, hypertriglycerolemia, high ALT, high uric acid. No significant association was found between non-alcoholic fatty liver and the use of betel nut.