去氧核醣核酸 (DNA) 的雙螺旋結構是自然界中廣為人知的一維線型結構，此一自組織之結構無論在水溶液或是一般乾燥環境中均有著高度穩定性與均一性，且其具有長度與結構之可調控性，若能與半導體基材結合，將可開發成為新型態之生物材料半導體元件。然而 DNA 的低導電性質限制了其於電子元件相關應用之發展。金屬化 DNA (M-DNA) 之開發不僅提升了 DNA 的導電性，並使此分子在室溫下具有微分負電阻之特性，可以作為新型態之生物／半導體複合元件的選擇。本文主要在介紹利用分子自組裝特性以及電化學分析技術，探討 M-DNA 的導電度差異與電化學特性。再利用這些特性將 M-DNA 導入生物感測器上的應用，以檢測出 DNA 序列中是否有錯誤配對的鹼基對。最後再以 Ni-DNA 分子製作成一個固態的奈米分子元件。

DNA is a one-dimensional nanowire in nature. Both conformation and size distribution of DNA are stable and uniform in solution and gas phase environments. Meanwhile, the length and conformation can be regulated by designing sequences. It is may not be utilized in nanodevices by integrating these biomaterials with semi-conductor substrate. However, the low conductivity prevents the application in devices usage. However, metal ions doped DNA possesses higher conductivity and can be integrated with semi-conductor substrate. Moreover these Ni-DNA molecules exhibit negative differential resistance (NDR) behavior. This finding provides a highly potential for constructing electrical nano-devices from biological molecules. This biomaterial is a unique and designable onedimensional bio-polymer for biosensiors and nanodevices usage. In this paper we will discuss the conductivity and electro-chemical properties by self-assembly and electro-chemical techniques. By using these properties the M-DNA (metallic DNA) can be used as a bio-detector for detecting single base mismatch of DNA. Furthermore, we