本實驗主要研究第二型糖尿病對骨質密度的影響。受測對象40人爲第二型糖尿病患者與38人正常受檢者。每位病患和正常受檢者均以雙能量X光骨質密度儀(GE Lunar PRODIGY(上標 TM), Madison, WI)分別測量他們正面的腰椎(L2-L4)及股骨頸(femoral neck)的骨質密度。運用統計上獨立t檢定說明男、女病患和正常受檢者之間的年齡、腰椎T-score和股骨頸T-score、身體質量指數(Bone mass index, BMI)的差異性，以直線回歸散佈圖分析BMD與BMI的相關強度、分佈情形以及相關危險比(Relative Risk, RR)來預測患骨質量不足或骨質疏鬆症機率。實驗結果顯示得知26位女性病患的平均BMI爲25.03±3.97，24位正常女性受檢者的平均BMI爲23.13±2.56，而14位男性病患的平均BMI值爲25.30±3.60，14位正常男性受檢者平均BMI值爲23.66±2.29。因此肥胖人易患有第二型糖尿病（男性RR爲1.04和女性RR爲1.13），且患病年限與骨質量不足或骨質疏顯症成負相關(RR<1)。由病患BMD與BMI回歸線散佈圖中，推論出第二型糖尿病的男、女性病患的股骨頸以及男性病患腰椎與肥胖所造成骨質增加的影響不大，唯有女性病患的腰椎骨質密度與肥胖程度是有正相關(P<0.05)。雖然胰島素所造成骨質密度增加並無相關，但是長期第二型糖尿病患股骨骨質密度減少，會增加日後股骨骨折的風險，因此必須要加強預防骨折的發生。

The purpose of the study was to assess the association between type 2 diabetes and bone mineral density (BMD). The study population included 40 diabetic patients and 38 control groups. All participants underwent lumbar spine and femoral neck by dual energy x-ray absorptiometry (DXA). The data analyses were perform with the independent t4est to explain the difference of age, T-Score at lumbar spine and femoral neck, bone mass index (BMI) between diabetes and subject without diabetes (P<0.05). Relative strength and linear regression scatter and relative risk (RR) were predicted the probability of osteopenia and osteoporosis. Type 2 diabetes mellitus indicated body mass indexes (BMI) >24 (25.03�3.97 in 24 diabetic women versus 25.30�3.60 in 14 diabetic men) consequently obesity tend to have this disease (RR=1.07 versus RR=4.13). Diabetic duration negatively associated with bone loss (RR<1). The linear regression scatter between BMI and BMD suggested that obesity did not effect on the BMD of type 2 diabetic women and men at femoral neck and diabetic men at lumbar spine, but the BMD of diabetic women at femoral neck associated with obesity (P<0.04). In conclusion, insulin did not correlate with incremental BMD and prevent long duration of diabetes from happening fracture at femoral neck.