本研究主要評估第二型女性糖尿病的骨質密度。受檢者對象爲年齡45-71歲（平均年齡爲59.16±8.09）的37位女性糖尿病和46-65歲（平均年齡爲53.49±6.08）的41位無糖尿病女性。全部受檢者均接受雙能量X光骨質密度吸收測量儀(dual energy X-Ray absorptiometry, DXA)測量腰椎(L2-L4)和髖骨(hip)等骨質密度檢測並填寫相關生活狀況的問卷。結果顯示第二型女性糖尿病腰椎和髖骨相較於正常受檢者有較高骨質密度，尤其髖骨骨質密度頗(p<0.05)。年齡除了對腰椎骨質異常（骨質疏鬆症或骨質量不足）危險度有增加外(RR0.34, 95% CI 0.15-0.75)，其餘危險因子對腰椎和髖骨的危險度並沒有顯著影響，包含初次月經年齡、停經年齡和經歷糖尿病時間。自迴歸分析中BMI與骨質密度關係，結果BMI與腰椎骨質密度成正相關有顯著性(p<0.05)，但與髖骨骨質密度成正相關但沒顯著性(p>0.05)。基於這些結果，此研究推論高胰島素對於髖骨質密度有所增值的影響，但是隨著年齡增長對於腰椎骨質流失是必須防備，此建議適度控制體重可以預防其他的疾病併發症發生。

The purpose of this study was to assess the effect of bone mineral density (BMD, g/cm^2) in women with diabetes. The study population included 38 diabetic women (aged 45-71, mean age of 59.16�8.08) and 41 women without diabetes (aged 46-65, mean age of 51.49�6.08). All participants underwent lumbar spine and hip by dual energy X-ray absorptiometry (DXA). The lifestyle was collected by direct interview using a structured questionnaire the results indicated that the diabetic women were higher BMD values than healthy women, especially in the hip (p<0.05). Except age elevated the risk of abnormal (osteopenia or osteoporosis) spine (RR 0.34, 95% CI 0.l5-0.75), the other risk factors were not significantly correlated with increased risk of spine and hip, including age at menarche, age at menopause, diabetic duration. The linear regression scatter between BMI and BMD suggested that obesity was positively associated with the BMD of diabetic women at the lumbar (p<0.05), but obesity did not effect on the BMD of diabetic women at the hip (p>0.05). On the basis of these results, the study demonstrated that insulin was correlated with incremental BMD at the hip, but it might be preventive for bone loss of lumbar spine with age. In conclusion, this study suggests that moderate regulated weight could prevent from disease which occur the other complications.