磁振造影檢查在臨床應用已二十餘年，這項檢查在醫學仁應用至今，經由軟體及硬體設備不斷改良更新，掃描所得影像可提供人體各部位器官組織良好的診斷資訊。在掃描脈衝序列方面，磁振造影提供一種檢查技術“磁化轉移”。此種技術藉由非共振前置飽和脈衝，將巨分子組織內束縛質子的磁化飽和後與周圍自由水質子之間產生交叉弛緩及化學變化，達到兩者磁化之間的平衡。磁化轉移技術，通常應用於注射對比劑後，與其他波序一起執行。注射對比劑後，病灶部位的信號明顯增強，磁化轉移技術將腦部除病灶之外的組織信號有效的降低，進而突顯出病灶區域。本研究嘗試以傳統注射對比劑前，掃描軸狀面T1加權自旋回波與軸狀面磁化轉移T1加權自旋回波，完成後，注射對比劑，並立即掃描軸狀面T1加權自旋回波與磁化轉移T1加權自旋回波四種不同腦部磁振脈衝序列影像，利用儀器提供的測量軟體，測量出腦部不同組織如灰質、白質、腦脊髓液及病灶處的信號強度，並以公式計算出各部位的磁化轉移率。藉此找出多發性硬化症患者腦部不同組織之間的信號差異與磁化轉移率。實驗結果顯示注射對比劑前T1加權自旋回波灰質、白質、腦脊髓液與病灶部位的信號強度分別爲752.2±20.5、901.5±23.1、407.2±17.2與691.8±45.8，注射對比劑後磁化轉移T1加權自旋回波信號強度分別爲577.3±25.9、596.5±29.0、398.3±20.1與1413.0±67.7，磁化轉移技術明顯的將腦部組織，如灰質與白質的信號強度降低，配合對比劑的使用進一步提供腦部多發性硬化症清楚的影像。

Magnetic resonance image (MRI) has been clinically applied on various medical fields for more than twenty years. Recent technical advances and updating of soft and hard wares make it possible to generate a detailed and clear image of anatomy and pathology of disease entities. One of these technique or scanning pulse sequence is the magnetic transfer contrast (MTC), which saturates the signals of bound proton in the macromolecules by means of off-resonance pre-saturation and interact with the free water proton through cross-relaxation or chemical exchange to lower the signal intensity of background tissue. For this reason MT imaging is commonly used in the MR research of Multiple Sclerosis (MS), a disease of the central nervous system (CNS), which is, among other things, characterized by destruction of myelin. MT imaging can for example be used to improve the contrast between the lesions which occur in the brain or the spinal cord and the surrounding tissue. MT imaging also enables us to assess the 'invisible' lesion burden in the normal appearing white matter, This research was designed to survey four different pulse sequence: pre-contrast transverse T1W Spin Echo, transverse T1W Spin Echo with MT and post-contrast transverse T1W Spin Echo, and transverse T1W Spin Echo with MT. All four techniques were setting to measure the signal intensity of gray matter, white matter, cerebrospinal fluid and MS plaque. All the data was calculated to the MTR, thus the differences between brain tissue and pathological changes can be obtained for further comparison The signal intensity measured from pre-contrast T1-weighted spin echo in four different brain tissues, gray matter, white matter, CSF and multiple sclerosis plaque was 752.2�20.5, 901.5�23.1, 407.2�17.2 and 691.8�45.8, and the signal intensity of post-contrast MT T1-weighted spin echo was 577.3�25.9, 596.5�29.0, 398.3�20.1 and 1413.0�67.7. The results showed that the MT technique efficiently reduced the signal intensity of normal brain tissue and thus enhanced the contrast difference of the pathological brain tissue, and by combination of contrast agent application, more detail and sophisticated image of the brain can be produced. Therefore, the application of the MTC is of great benefit for MM study of the brain.