本研究使用定量式超音波，評估血液透析合併糖尿病病患對於骨質結構與骨質轉換率關係，是否容易骨質疏鬆症，以預防骨折之發生率。全部受檢者爲134位，34位血液透析病患，年齡介於26-80歲（平均年齡爲63.4±11.2歲），接受血液透析平均42.5個月，與100位的正常受檢者，年齡介於48-82歲（平均年齡爲62.9±6.6歲）。全部受檢者均接受定量式超音波測量右側跟骨(calcaneal)之骨質檢測，並填寫相關生活狀況的問卷。結果顯示血液透析音波速度(speed of sound, SOS)、寬頻衰減值(broadband ultrasound attenuation, BUA)與定量超音波指數(quantitative ultrasound index, QUI)相較於正常受檢者，並沒顯著性的差異(p>0.05)。相關係數分析後血液透析病患體重與QUS參數呈現正相關，且有統計顯著性(p<0.01)，BMI與QUI、SOS呈現正相關，在統計上有顯著性(p<0.05)。鹼性磷酸酵素(Alk-P)與BUA成負相關顯著性(p<0.05),Ca、p、i-PTH、Cr與QUS參數呈現正相關，但沒有統計上差異(p>0.05)。此研究結果發現血液透析合併糖尿病病患相較於正常受檢者並無嚴重流失骨質密度，但是隨著血液透析時間增長，所造成的骨質密度流失是需要留意的，並建議固定測量骨質狀況，爲降低骨折發生率。

The aim of the study was evaluated the relationship between bone quality and bone turnover rate in hemodialysis with diabetic patients by using quantitative ultrasound. To prevent mortality rate of fracture whether easily cause osteoporosis. One hundred and thirty-four subjects were enrolled in this study. Among them were 34 patients with hemodialysis with diabetic (age 26-80 years, mean age of 63.4±11.2 years, duration of dialysis 42.5 month) and 100 normal controls (age 48-82 years, mean age of 62.9±6.6 years). The bone quality of right calcaneal was measured by using quantitative ultrasound (QUS). Anthropometric data and reproductive history were collected from with questionnaire. No significant differences were found between hemodialysis and normal controls at QUI、 BUA、 SOS. In hemodialysis patients, all QUS parameters (SOS, BUA, QUI) were positively association with weight and BM1 (p<0.01, p <0.05, respectively). In contrast, the negatively association the were between Alk-P and BUA (p<0.05). Although there were negative relationship between biochemical parameter (Ca, i-PTH, Cr) and all QUS parameters, the statistically significant did not achieve (p>0.05). The study suggested hemodialysis patients with diabetic compared could not been serious bone loss, when compared with controls subjects. We considered if increase dialysis period the occasion of bone loss was needed notice. Therefore, regular monitored bone quality to prevent the fracture rate became more important in long term hemodialysis patients.