五味子 (Schisandra chinensis, SC) 為亞洲國家常用之傳統草藥，目前已知其藉由提升肝臟抗氧化系統以達到護肝效果。本研究目的在探討以高脂高膽固醇飲食的條件下，五味子萃取物對倉鼠體內脂質代謝之影響。
將雄性倉鼠隨機分成正常飼料之對照組(含5%油脂，ND)、含8%油脂與0.2%膽固醇飼料之控制組 (Control) 及控制組飼料分別添加不同比例五味子萃取物之試驗組 (LSC及HSC)。結果顯示，在飼料中添加高劑量五味子萃取物可明顯降低血清中低密度脂蛋白膽固醇及三酸甘油酯濃度，同時延長低密度脂蛋白膽固醇之氧化遲滯時間；在肝臟脂質及抗氧化方面，五味子萃出物可降低三酸甘油酯及肝臟硫代巴比妥酸反應物質 (Thiobarbituric acid reactive substances, TBARS) 含量。綜合以上結果顯示，五味子萃取物的給予，可改善高油高膽固醇飲食倉
鼠之血清低密度脂蛋白膽固醇及三酸甘油酯含量，降低心血管疾病發生機率，同時改善其體內氧化壓力。

Schisandra chinensis (SC) is a famous traditional medicine in Asia and has been used to protect liver
from damage by enhancing the hepatic antioxidant system. The objective of this study was to investigate
the effects of S. chinensis extract on lipid metabolism and peroxidation levels in hamsters with high fat and
high cholesterol diet. Hamsters were randomly divided into four groups, including normal diet group fed
diet containing 5% oil without cholesterol (normal diet, ND), control group fed diet with 8% oil and 0.2%
cholesterol (control) and treatment groups fed the control diet with 0.4% (LSC) or 0.8% (HSC) S. chinensis
extract. The triglyceride contents in both blood and liver were significantly decreased in HSC group. The lowdensity
lipoprotein cholesterol (LDL-C) concentration was also reduced in serum. In addition, HSC inhibits
the formation of hepatic thiobarbituric acid reactive substance (TBARS) values and prolongs the lag phase of
LDL oxidation. These results indicate that the S. chinensis extracts can modulate lipid metabolism and reduce lipid oxidation in the hamster model fed a high fat diet.