發展非侵入性的幽門桿菌診斷方法一直是科學家努力的目標。尿素呼吸試驗是快速、簡單、適用於不同類型胃部疾病患者的首選。糞便抗原檢測也被廣泛地應用於大人或小孩根除幽門桿菌前後的比較。聚合.連鎖反應由於需要胃黏膜進行檢測，因而被歸類為侵入性檢查，但是其能快速提供幽門桿菌致病因子和對抗生素 macrolide 敏感性等相關資訊，對於一些特殊檢體的檢測不失為良好的選擇。

Development of non-invasive diagnosis of H. pylori has been the scientists’ goal. Urea breath test is fast, simple,and the first choice to the different types of gastric diseases of patients. Stool antigen tests have been extensivelyused in pre- and post-treatment settings both in adults and children. Polymerase chain reaction (PCR), which hasbeen classified as invasive examination, is able to rapidly provide the information about the H. pylori virulence factors, susceptibility to macrolide, and to detect H. pylori in non-conventional specimens.0