本研究以醫師與藥師之觀點，探討影響採用處方箋釋出系統的關鍵因素。方法：以資訊系統成功模式為理論基礎，並結合社會連帶觀點來建構研究模式，而研究對象為參與行政院衛生署處方箋釋出資訊平台推廣計畫之醫師與藥師，透過問卷收集資料並以複迴歸方法進行分析。結果：(一)系統品質是影響醫藥師系統使用的關鍵；(二)系統開發人員的服務品質不影響醫藥師系統使用與使用者滿意；(三)處方箋釋出資訊系統的資訊品質不影響醫藥師使用者滿意；(四)影響醫師使用者滿意的是系統品質，而影響藥師使用者滿意的是系統使用；(五)互動關係與信任對系統使用、使用者滿意有直接的影響。結論：醫藥師對系統使用與使用滿意度會影響淨效益，而系統品質是醫藥師決定系統採用與否的關鍵因素。除了系統特性之外，人際互動也會影響系統使用與滿意度，因此在系統建置過程中應更加強互動，以提高醫藥師的系統使用與使用滿意度。

Objectives: The aim of this study was to understand the critical factors influencing the adoption of the Release of Prescription Information System (RPIS) from the perspectives of physicians and pharmacists based on the Information System Success Model and Social Ties.Methods: A survey was conducted to identify those factors that affected the adoption of theRPIS. Subjects were physicians and pharmacists who joined the RPIS project. Multiple regression analysis was used to investigate the factors which were most influential in the adoption of the system. Results: System quality was the key factor influencing system use; service quality did not influence system use and user satisfaction; information quality did not influence user satisfaction;system quality influenced user satisfaction from the physicians’ perspective and system use influenced user satisfaction from the pharmacists’ perspective; rapport and trust had a significant and positive influence on system use and user satisfaction. Conclusions: Both system use and user satisfaction influenced net benefits. Physicians and pharmacists were most concerned about system quality. In addition to system characteristics, the interaction affected system use and user satisfaction. System developers should have more interaction with physicians and pharmacists during system implementation in order to improve system use andusersatisfaction.