心電圖QTc間隔的延長，為抗精神病藥之重要副作用之一。Amisulpride為一被認為對心電圖相對安全之抗精神病藥物，造成心臟問題之報告較少。吾人在此報告二例無心臟病史之患者，因注射皮下長效抗精神病藥物與amisulpride高劑量使用而發生QTc的延長。病患一為37歲女性，之前無心律不整病史。之前使用長效flupenthixol decanoate也未有心臟方面影響。其在同時使用每週長效之flupenthixol 注射及每日口服amisulpride 1400mg後，發生了QTc的延長。此一心電圖之變化在病患將口服藥物更換後恢復正常。病患二是38歲女性，在同時使用haloperidoldecanoate 50mg長效針劑注射一次與每日amisulpride 1400mg使用七天之後發生了致命性心律不整。經過急救之後的心電圖發現有QTc的延長，此情形在停用amisulpride三天後得到緩解。兩例都僅在兩藥同時使用時產生此一副作用，可能與對human Ether-a-go-go Related Gene (hERG)鉀離子通道之加成作用有關。

Antipsychotic drugs may cause prolongation of the heart rate-corrected QT interval (QTc).Amisulpride, a relatively new atypical antipsychotic drug, has been considered to have few cardiac adverse effects, except in cases of overdose. We report 2 schizophrenic patients with no history ofcardiac disease who developed significant QTc prolongation after concurrent use of intramuscular depot injections of typical antipsychotics and high-dose amisulpride. A 37 year-old woman, had no known history of arrhythmia.
Previous exposure to flupenthixol decanoate had not resulted in
cardiotoxicity. She was treated with weekly depotinjectionsofflupenthixol and with amisulpride 1400mg/day, after which QTc prolongation was noted. The electrolytes were normal. The ECG normalized when we switched from amisulpride to another antipsychotic medication. Another patient was a 38 year-old woman who had a cardiac arrest after 7 days of concurrent use of haloperidol decanoate 50mg and amisulpride 1400mg/day. She was resuscitated but was seen to have QTc prolongation on subsequent ECGs. This abnormality resolved within 3 days after amisulpride was discontinued. In both cases, it was only the simultaneous administration of 2 drugs that was associated with the adverse effect. It is possible that the combination had an additive effect on the human Ether-a-go-go Related Gene (hERG) potassium channe