篇名 | Water-soluble Phenolic Compounds and Their Anti-HIV-1 Activities from the Leaves of Cyclocarya paliurus |
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卷期 | 18:6 |
作者 | Juan Zhang 、 Ning Huang 、 Lu, Jin-cai 、 Xu Li 、 Wang, Yun-hua 、 Yang, Liu-meng 、 Zheng, Yong-tang 、 Kai Xiao |
頁次 | 398-404 |
關鍵字 | Cyclocarya paliurus 、 phenolics 、 flavonol glucuronides 、 anti-HIV-1 activity 、 Juglandaceae 、 MEDLINE 、 Scopus 、 SCIE |
出刊日期 | 201012 |
Eight phenolic compounds including five glucuronides were isolated from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja, which is used as a source of tea. Their structures were characterized by spectroscopic methods. The results of biological assay showed that compounds 1 and 5 had good activities against HIV-1 induced cytopathic effects in C8166 lymphocyte at non-cytotoxic concentrations, with EC50 values of 31.74 and 10.76 μM, and therapeutic index (TI) values of >13.02 and 25.46, respectively. Relationship between molecular structures and their bioactivities was discussed.