本研究以國內多淚二萃瞇(polybrominateddiphenyl ethers， PBDEs)使用量最高之樹脂業 為研究對象，考量其2003-2006總使用量及逐年使用分布後，選取一家位於台灣南部之耐燃樹脂製造廠，針對該廠勞工，進行血液中22種PBDEs同源物量測，健康、飲食及時間活動模式問卷調查，同時量測工人13項血液生化與5項荷爾蒙等健康指標，並整合各項指標後進行勞工多淚二萃瞇暴露及健康影響評估。本研究選取41位勞工依據職稱及作業內容並以時間活動模式資料確認後，區分為高(耐燃樹脂成品製造)、中(耐燃樹脂成品加工:裁切及包裝)、低(行政人員)暴露組，高、中、低暴露組勞工血中PBDEs平均濃度分別為1149.11、49l.59與102.42月/glipid，統計顯示高暴露組濃度顯著高於中、低暴 露組(p

In Taiwan, the highest amount of Deca-BDE was used in synthetic resin industry since 2003 to 2006 year. The aims of this study are to determine the association between serum levels of 22 PBDE congeners and health index (13 blood biochemistry and 5 hormone examinations) for workers of a representative synthetic resin plant in southern Taiwan, and then to integrate health outcomes, exposure matrix and time activity pattern to assess the occupational PBDEs exposure and health outcomes. 41 workers were grouped to three groups including manufacture (high exposure), processing (medium exposure), and officers (low exposure) by job title, PBDEs exposure possibility and time-activities data were also investigated for double-check. The average serum PBDEs levels were 1149.11, 491.59 and 102.42 ng/g lipid in high, medium and low exposure groups, respectively. The average level of PBDEs in high exposure group was significantly higher than those in other groups (p<0.0001). The dominant congeners in serum samples were BDE-209, BDE-197 and BDE-207. Moreover, the T3/T4 was significantly correlated with increasing levels of total PBDEs (p=0.0117), BDE-206(p=0.0345), BDE-207 (p=0.0034) and BDE-197 (p=0.003). We further divided all workers into two groups by serum
PBDE levels, and we found the T4 levels in high serum PBDE group were significantly lower than low serum PBDE group (p=0.0220). It implied that T4 levels may be decreased by elevated PBDEs levels. In conclusion, we recommend that the manufacturing process need to improve and the workers in synthetic resin industry should enhance hazard education and equip personal protective equipments. We also suggested that PBDEs occupational exposure workers should check on T4 level regularly.