Transient mid-ventricular ballooning syndrome is a variant form of Takotsubo cardiomyopathy (TTC). The precipitating factors and clinical course arc similar, and the clinical manifestations mimic those of acute coronary syndrome, which are characterized by transient left ventricular dysfunction without significant coronary artery disease. Takotsubo cardiomyopathy with transient left bundle branch block (LBBB) is rare. Herein, we describe the case of a 64-ycar-old woman who had a transient mid-ventricular apical ballooning syndrome. Electrocardiography (ECG) revealed a transient LBBB.