Pheochromocytoma is a neuroendocrine tumor, characterized by an excess of catecholamine production, which results in paroxysmal or sustained hypertension, even hypertensive crisis. The classic triad of
pheochromocytoma is paroxysmal headache, sweating and palpitation. Myocarditis is a rare manifestation of pheochromocytoma. We report 2 middle-aged women with a long history of hypertension and headache, presenting initial symptoms mimicking acute coronary syndrome and finally developing heart failure and unstable hemodynamics. The characteristic fluctuation of blood pressure and hypertensive crisis prompted us to further survey and diagnose this rare pheochromocytoma-related myocarditis.