篇名 | The Imaging Behavior of an MRI Contrast Agent [Gd(TTDA-BOM)]2- in a Mice Liver Tumor Model at 3 Tesla |
---|---|
卷期 | 30:3 |
作者 | Jao, Jo-chi 、 L, Hsiang-chin 、 Lu, Hsin-ying 、 Wang, Yun-ming 、 Liu, Gin-chung 、 Lin, Li-min 、 Chu, Pei-yu 、 Chen, Shih-hsie 、 Chen, Po-chou |
頁次 | 139-144 |
關鍵字 | Magnetic resonance imaging 、 Paramagnetic contrast agent 、 Gd 、 Liver 、 Tumor 、 3T 、 EI 、 SCI |
出刊日期 | 201006 |
[Gd(TTDA-BOM)]2−is a newly developed paramagnetic contrast agent. The aim of this study was to investigate the magnetic resonance imaging (MRI) behavior of [Gd(TTDA-BOM)]2−in mice with implanted AS-30D (Chang
hepatoma ascites, CHA) tumor in liver at a 3T high-field whole-body magnetic resonance (MR) scanner. The high-field MR scanner is expected to have a higher signal-to-noise ratio (SNR). The dynamic MRI studies show that the signal enhancement in liver is larger than that in tumor, so that the contrast-to-noise ratio (CNR) between liver and tumor
increases after [Gd(TTDA-BOM)]2−injection. During one-hour investigation, it was found that [Gd(TTDA-BOM)]2−could stay in liver up to one hour. On the contrary, [Gd(DTPA)]2−, a kind of commercial contrast agent, was excreted from liver quickly. Therefore, the CNR between liver and tumor using [Gd(TTDA-BOM)]2−is larger than that using [Gd(DTPA)]2−and remains high at least up to one hour. In conclusion, [Gd(TTDA-BOM)]2−might have good potential for being a hepatobiliary MR contrast agent.