目的:本篇研究的主要目的是想找出充血性心衰竭病人長期預後的預測因子。方法:共有30個正在進行心臟復健的住院病人參與研究。在住院期間,這30個住院病人進行了疾病嚴重度、功能、和殘障程度的測量。在疾病嚴重度方面:心室射出率、股四頭肌在60°/sec和120°/sec角速度最大力矩,股四頭肌疲乏;功能方面:紐約心臟學會分級、六分鐘行走測試、起立與走計時測試;殘障方面:明尼蘇達心衰竭問卷。這些測量將作為預後的預測因子。受試者在出院後平均追蹤了26.9個月以評估預後。預後的評估內容包括:死亡率、生活品質評估、心臟疾病引起的住院天數。結果:在追蹤期間內,9個受試者(30%)死亡,住院期間的測量因子與死亡率沒有顯著相關。在12個受試者中,7個受試者再度因心臟病疾病住院。統計分析後發現「六分鐘行走測試」與「起立與走計時測試」合起來占40.3%(P<.05)生活品質的變異。在26.9個月追蹤中,股四頭肌在60°/sec角度速度最大力矩可顯著預測心臟疾病引起的住院天數。結論:由本篇研究結果發現,充血性心衰竭病人在住院期間若在「六分鐘走路測試」與「起立與走計時測試」等活動功能性測試表現較好,便有機會擁有較好的生活品質。臨床治療時可藉由提高病人的功能性活動來提升他們的生活品質。
Purpose: The purpose of this study was to identify the predictors of long term outcomes in patients with congestive heart failure (CHF). Methods: Thirty acute cardiac rehabilitation patients with CHF underwent subjective and objective measures, including impairment (ejection fraction, quadriceps peak torque at 60 and 120°/sec (PT60, PT120), quadriceps fatigue), function (New York Heart Association Class, six minute walk test (6MWT), timed "Up&Go" (TUAG)), and disability (Minnesota Living with Heart Failure Questionnaire (LHFQ)) in a previous study during their hospitalization. Subjects were followed up for a mean of 26.9 months. The long term outcomes were mortality, quality of life (QoL) questionnaire, and cardiac-caused hospitalization days. Results: During the follow up period, 9 subjects (30%) died. No significant correlation was found between the premeasures and mortality. Among the 12 contacted survivors, 7 were rehospitalized due to cardiac-caused events. In the multivariate analysis, the combination of TUAG and 6MWT accounted for 40.3% of variance in long term quality of life (p<.05). The PT60 was an independent predictor of cardiac-caused hospitalization days over the 26.9 month follow- up (p<.05). Conclusion: Patients with CHF who initially performed well on the TUAG and 6MWT tended to have better long term QoL. Clinicians may improve patients' QoL by increasing their physical activity level.