背景與目的：慢性阻塞性肺部疾病患者通常有運動功能降低的現象，臨床上有不同運動測試方法用以評估其運動功能。本研究主要目的是檢驗慢性阻塞性肺疾病患者其不同運動表現指標之絕對値與校正値的相關性，以及這些指標與疾病嚴重度的相關。方法：16位男性慢性阻塞性肺部疾病患者分別接受6分鐘行走測驗和漸進式運動測試。主要運動功能指標包括：6分鐘行走距離(6MWD)，6分鐘行走功率(6MWD×W)，最高攝氧量和最高輸出功率。這些數值分別以絕對值和經年齡及體型校正後的標準數值呈現。結果：疾病嚴重度與6分鐘行走距離，6分鐘行走功率，最高攝氧量的絕對值以及最大攝氧量的校正值有統計上顯著相關（r值分別為0.55，0.61，0.71，及0.62，p<0.05），但最高輸出功率之絕對值與校正值均無顯著相關。身體質量指數與淨體組織指數之絕對值或校正值與所有運動功能參數（除6MWD外）均有統計上顯著相關(p<0.05)。漸進式運動測試所得之運動功能指標與6MWD×W之相關性比與6MWD間的相關性更强。結論：慢性阻塞性肺部疾病患者之疾病嚴重度與最高攝氧量的絕對值相關性最強。兩種運動測試的各項運動功能指標相當一致，且標準化程序的確會影響這些關係的表現。

Background and Purpose: Exercise is often impaired in patients with chronic obstructive pulmonary disease(COPD). Various test protocols have been used to assess exercise performance in these patients. The purpose of this study was to examine the correlations between different indices of exercise performance in absolute and normalized values measured during 6-minute walk test(6MWT)and graded exercise test(GXT),and their relationship with disease severity in patients with moderate-to-severe COPD. Methods: Sixteen male patients with COPD(mean ± standard error of forced expiratory volume in ones econd (FEV1)=45.3±3.3% predicted)underwent 6MWT and GXT. Main exercise performance indices were distance walked in 6-minute(6MWD), 6-minute walk work(6MWD×W)that was calculated as 6MWD multiplied by the body weight, peak oxygen uptake(VO(subscript 2peak)),and peak power output (W(subscript peak)).These values were expressed as absolute values and as percentage of the predicted value, adjusted for age, race and gender. Results: The disease severity(i.e.% predicted) correlated significantly with absolute 6MWD(r=0.55), 6MWD×W(r=0.61), and absolute and normalized VO(subscript 2peak)(r=0.71 and 0.62,respectively),but not with absolute and normalized W(subscript peak) (r=0.36 and 0.35,respectively). Body mass index and fat free mass index correlated with all exercise performance indices measured during GXT and 6MWT,except for the 6MWD whether normalized or not. The value of6MWD×W had stronger relations with those exercise performance indices measured during the GXT than 6MWD.Conclusions: In patients with COPD, disease severity was best correlated with VO(subscript 2peak)in absolute value. There were good correlations between different indices of exercise performance measured during 6MWT and GXT and the normalization did affect these correlations.