類鼻疽的致病菌為類鼻疽伯克氏菌(Burkholderia pseudomallei),人類因直接接觸、吸入和食入病源菌而感染。類鼻疽為伺機性感染,病症表現從急性到慢性,從局部到全身性,都有可能,若併發敗血性休克,則死亡率更是超過八成。此菌感染最重要的危險因子包含糖尿病、酗酒和慢性腎臟病。對於類鼻疽,及早且正確的抗生素治療,可有效降低死亡率,整體抗生素治療時間需達至少十二週以上,病人服藥順從性對於治療是否成功有著巨大的影響。本病例為一46歲女性,因家中水患,協助清理家園,六日後發生高燒、頭痛、乾咳等現象。前往本院急診,最初臆斷為左上葉肺炎收入院治療。住院後診斷出有糖尿病且合併酮酸中毒,血液培養報告證實為類鼻疽伯克氏菌感染,經適當治療後,病人病情改善,出院後持續給予口服抗生素治療。
Pheochromocytoma is the proliferation of chromaffin cell-formed tumors. Pheochromocytoma was first recorded in 1886 by Frankel. Malignant pheochromocytoma is relatively rare, accounting for approximately 10% of cases. In benign and malignant pheochromocytoma, the histological and biochemical characteristics were indistinguishable. Currently, the pathological definition of malignant pheochromocytoma is a local invasion or distal metastasis, and early diagnosis it is difficult. This study indicated that the distal metastasis occurs 20 years after surgical resectioning whether benign or malignant, necessitating long-term follow up. The best treatment for malignant pheochromocytoma is surgical resectioning, early diagnosis, and early treatment. Therefore, this study examines the genetics, pathology, and biochemistry to suggest several solutions to enable early diagnosis. This study analyszes a case of pheochromocytoma to present the diagnosis and treatment methods of benign and malignant pheochromocytomas.