目的：台灣1978年全面實施麻疹疫苗接種後，自1989年起不曾發生麻疹大流行。多數成人的麻疹免疫力主要來自幼兒期預防接種，疫苗的保護力可能隨時間過去而逐漸消失。本研究針對台南科學園區成年勞工探討血清麻疹抗體流行病學。材料與方法：本研究以橫斷式研究設計，用病歷回顧的方式來收集2007年7月至2008年2月期間至本院台南科學園區附設診所的員工年度健康檢查結果，並分組比較1978年麻疹全面預防接種前後之血清麻疹抗體陽性率。結果：研究個案總數為970人，女性323位，男性647位，全體麻疹抗體陽性率為89.2％。男性的麻疹抗體陽性率比女性高90.9％：85.8％, p=0.016)；1978年前出生者的抗體陽性率比1978年後出生者高88.6％：82.7％)。1978年以前出生者比1978年以後出生者的麻疹抗體吸光值中位數高0.7：0.45, p＜0.001)。男性麻疹抗體陽性的低密度膽固醇値異常者比麻疹抗體陰性者多p=0.009)；男性和女性麻疹抗體陽性的總膽固醇値異常者比麻疹抗體陰性者多p=0.017；p=0.032)。單變項邏輯式迴歸分析發現：男性相較於女性麻疹抗體陽性率之勝算比為1.66p=0.016)；1978年以後出生者相較於1978年以前出生者的勝算比為0.63p=0.033)。多變項邏輯式迴歸分析， 經調整性別及1978 年前後出生者， 發現無明顯差異p=0.07,p=0.155)。1967年以前出生者的血清麻疹抗體陽性率為100％；1968-1977年出生者的麻疹抗體陽性率為85.9-98.1％；1978-1983年出生者的麻疹抗體陽性率為80.6-94.6％；1984及1985年出生者的麻疹抗體陽性率分別為70％和66.7％。結論：本研究發現1978年以前出生者的麻疹抗體陽性率比1978年以後出生者高；男性
和女性麻疹抗體陽性的總膽固醇値異常者比麻疹抗體陰性者多；男性及1978年以前出生者麻疹抗體陽性率比女性及1978年以後出生者高。

Purpose: Ever since universal measles vaccination program in Taiwan in 1978, no measles outbreak had occurred since 1989. Immunity to measles in most adults is mainly from routine childhood immunizations. However, measles vaccine may reduce its protective effect gradually with time. We designed this study to review the epidemiology of measles among adult workers in the Tainan Science-based Industrial Park. Material and methods: We carried out a retrospective, cross-sectional study by reviewing annual employee health exam results, collected from medical records in Tainan Science-based Industrial Park clinic from July 2007 to February 2008. The study sample was divided into two groups: those born before and after 1978, when the universal measles vaccination program was implemented, and we then compared the seropositivity rates for measles antibody (Ab) in them. Result: A total of 970 subjects (323 female; 647 male) were recruited and overall seropositivity rate of measles Ab was 89.2%. The seropositivity rate of measles Ab in male is higher than that in female (90.9%：85.8%, p=0.016); the seropositivity rate of measles Ab in subjects born before 1978 is higher than that in subjects born after 1978 (88.6%：82.7%). The median of optical density of measles Ab in subjects born before 1978 is higher than that in subjects born after 1978 (0.7： 0.45, p＜0.001). The seropositivity rate of measles Ab in male who revealed abnormality of cholesterol- low density lipoprotein level is more than seronegativity rate of measles Ab in male (p=0.009). The seropositivity rate of measles Ab in male and in female who revealed abnormality of total-cholesterol level is more than seronegativity rate of measles Ab in male and in female (p=0.017; p=0.032). Univariate logistic regression analysis revealed that odds ratio of seropositivity rate of measles Ab in male competed with that in female is 1.66 (p=0.016); odds ratio of seropositivity rate of measles Ab in subjects born after 1978 competed with that in subjects born before 1978 is 0.63
(p=0.033). The seropositivity rate of measles Ab was 100% in subjects who were born before 1967,85.9%-98.1% in those born between 1968 and 1977, 86.2%-94.6% in those born between 1978 and 1983, 70% in those born in 1984, and 66.7% in those born in 1985. Conclusions: This study revealed that the seropositivity rate of measles Ab in subjects born before 1978 is higher than that in subjects born after 1978; the seropositivity rate of measles Ab in male and in female who revealed abnormality of total-cholesterol level is more than seronegativity rate of measles Ab in male and in female; the seropositivity rate of measles Ab in male and in subjects born before 1978 that were higher than that in female and in subjects born after 1978.