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美容科技學刊

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篇名 聚麩胺酸/聚乙烯醇混摻薄膜接枝左旋維他命C之研究
卷期 6:1
並列篇名 Investigation of PGA/PVA Blend Membrane Grafted with L-vitamin C
作者 蘇德利楊銘乾劉憓陵
頁次 077-094
關鍵字 聚麩胺酸聚胜肽聚乙烯醇戊二酫左旋維他命C化妝品PGAPolypeptidesPVAGlutaraldehydeAscorbicCosmetic
出刊日期 200903

中文摘要

Na+-γ-Poly (glutamic acid) (PGA)為一具有奇佳的高吸水性、生物可分解性、保濕性、無毒性等優良特性之高分子聚合物,因此用來與聚乙烯醇(PVA)泥摻製成薄膜。兩種高分子在室溫下且不需任何化學藥劑的條件下PGA和PVA即可混合形成水膠。依不同比例之PGA/PVA (0%、10%、11.1%、12.5%、20%、273%、30%、40%、50%)混摻薄膜測試在生理食鹽水中之膨潤度,證實其具有高吸濕性,之後以戊二酫與左旋維他命C共價結合,運用左旋維他命C之抗氧化能力,期能增加PGA/PVA混摻薄膜在生醫材料及化妝保養品產業上的應用。

英文摘要

Na+-γ-poly (glutamic acid) (PGA), a highly water-soluble, biodegradable, hygroscopic and non-cytotoxic polypeptides, was chosen to fabricate the PGA/polyvinyl alcohol (PVA) blending membranes. By mixing PGA and PVA together, a hydrogel would be formed at room temperature without any chemical treatment. It was proven to be a highly hygroscopic by mixing at different ratio of PGA/PVA (0~50%) blending membranes for testing its swelling ratio in normal saline. By glutaraldehyde to covalently bond L(+)-Ascorhic acid with PGA/PVA, the application of PGA PVA blending membranes can be broadened in medical devices and cosmetic indststries.

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