近年來，老化與自由基兩者的關係常被探討。其中，以活性氣物質(reactive oxygens species; ROS)的產生有關，活性氣可以引發人體內脂質中的不飽和脂肪酸過氣化，而產生脂質過氣化的最終產物丙二醛(malondialdehyde; MDA)。本實驗以老化促進小鼠(Senescence-accelerated mice prone 8; SAMP8)為實驗動物對象，區分3月、5月及l歲齡等三階段的老化促進小鼠，探討老化促進小鼠的腦組織、肝組織與心臟組織之不同年齡階層丙二醛的改變老化促進小鼠(SAMPS)藉由其本身老化加速之生理特性，常被用來探討因老化所引起的學習與記憶障礙的研究模式。由本實驗結果發現，隨著年齡的增加，老化促進小鼠的腦組織與心臟組織之丙醛的含量有增加的趨勢。

In the recent years, the correlation between aging and free radicals is discussed. Especially, the reactive oxygen species are the most popular topics. The reactive oxygen species could induce the unsaturated fatty acids peroxidation which proceeded a series of biochemical reactions and then the malondialdehyde produced. In this study, the SAMP8 mice were divided into three groups including 3 months, 5 months and one year old. The malondialdehyde amount of brain, liver and heart tissues in SAMP8 mice were explored. Besides, the senescence-accelerated mice prone 8 was the learning and memory deficits model that was a characteristic of its age-accelerated in physiological function. From the results of this experiment, there is a tendency that as the MDA amount of brain and heart tissues in SAMP8 mice was increasing as the ageing adding.