A sensitive, accurate, precise and reliable HPTLC method has been proposed for determination of Ciclesonide and Fluticasone propionate - two widely used novel steroids in bulk as well as in pressurized metered dose preparations. Ciclesonide and Fluticasone propionate resolved
well in toluene: ethyl acetate: formic acid (7: 3: 0.1 v/v/v) with respective Rf values 0.46 ± 0.004 and 0.43 ± 0.012 and could be scanned at 242 nm and 236 nm respectively. Linearity was observed in the range of 400 – 1100 ng band-1 for Ciclesonide and 200 – 1000 ng band-1 for
Fluticasone propionate. The method was validated as per ICH guidelines and successfully applied for quantification of Ciclesonide and Fluticasone propionate in their commercial metered dose formulations. The method was found to be less time consuming as well as cost effective for
routine analysis.