目的：本研究目的在於評估肝癌患者營養狀況與生活品質，並分析其生活品質的預測因子。材料與方法：自 2007 年 8 月至 2009 年 3 月，於中部某醫院放射腫瘤科門診肝癌病患共有 300
名受邀參與研究。研究對象需滿 18 歲以上，最近一個月內未接受治療，意識清醒、具語言及表達能力，且同意接受訪談者為限。以簡易營養評估量表、血液生化指標及歐洲癌症治療與研究組織生活品質問卷，評估病患之營養狀況與生活品質。結果：近半數（45.7%）的肝癌個案有營養問題，且與肝硬化程度呈現顯著差異（χ2 = 21.218, p<0.001）。病患之「整體生活品質及健康狀況」不佳，但其「整體生活品質功能狀態」尚稱良好。綜合分析疾病變項、生化指標及營養評估對於整體生活品質之影響，其中的自我營養評估、一般營養評估、飲食評估與 AFP 為「整體生活品質及健康狀況」的預測因子；而一般營養評估、飲食評估、自我營養評估、體位評估與 AFP 為「整體生活品質功能狀態」的預測因子。結論：肝癌患者的營養狀態為整體生活品質之重要預測因子。營養篩檢與評估對肝癌病患有其必要性，而早期營養照護之介入與支持將有助於改善肝癌病患的生活品質。

Purpose : The aims of this study are assessing the nutritional status and quality of life (QoL) in the patients with hepatocellular carcinoma, and analyzing the predictors of QoL.Materials and Methods : From August 2007 to March 2009, three hundred outpatients with hepatocellular carcinoma at the Department of Radiation Oncology, a teaching hospital in central
Taiwan consented to participate in this study. The scores of the Mini-Nutrition Assessment (MNA),the European Organization for Research and Treatment of Cancer Quality of Life Core-30 (EORTC QLQ-C30), and the data of routine biochemical tests were collected to evaluate the nutritional status and QoL.Results : Almost half of the patients (45.7%) had problems in nutritional status. The nutritional status of the patients was significantly related with the grade of liver cirrhosis (χ2 = 21.218, p < 0.001).The levels of global health status were not well, but the levels of the global functioning status were still satisfied. Analyzing impact of the variables on the QoL, the predictors of global health status
were self-nutritional assessment, general nutritional assessment, diet assessment and AFP; general nutritional assessment, diet assessment, self-nutritional assessment, anthropometric assessment and AFP were the predictive factors of global functioning status.Conclusion : The nutritional status is the predictor of global QoL in the patients with hepatocellular carcinoma. Nutritional screening and assessment are necessary for liver cancer patients. In addition,nutritional intervention and support should be beneficial to improve the QoL for those patients.