篇名 | Angiotensin-I Converting Enzyme Gene Polymorphisms and the Risk of Venous Thromboembolism in an Ethnically Chinese Population Living in Taiwan |
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卷期 | 27:4 |
作者 | Hsieh, Chien-an 、 Ko, Yu-lin 、 Hsu, Tsu-shiu 、 Chang, Chi-jen 、 Teng, Ming-sheng 、 Wu, Semon 、 Hsu, Lung-an |
頁次 | 252-258 |
關鍵字 | Angiotensin converting enzyme 、 Polymorphism 、 Genetics 、 Venous thromboembolism 、 MEDLINE 、 SCI 、 Scopus |
出刊日期 | 201112 |
Background: There have been conflicting reports of the association between the insertion/deletion (I/D)polymorphism of the angiotensin-converting enzyme (ACE) gene, and the risk of venous thromboembolism (VTE).We sought to investigate the association between ACE I/D polymorphism, and the risk of VTE in a Chinese population living in Taiwan.Methods: 176 patients with VTE and 321 age and sex-matched controls were analyzed for the ACE I/D =polymorphism by polymerase chain reaction.Results: The genotype distribution of the ACE I/D polymorphism was not statistically different between the VTE affected subjects and the group of unaffected subjects (p = 0.057).Notably, the frequency ofACEDallele in patientswith VTE were significantly lower than that in the control group (28% vs. 35%, p = 0.018). After adjusting for age, gender,smoking, hypertension, diabetes and bodymass index (BMI),
theACEDallele carriers remained significantly associated with a decreased risk of VTE. Furthermeta-analysis by pooling data from 15 studies revealed that neither the DD, nor the II genotype, was found to be associated with VTE (pooled unadjusted odds ratio were 1.167, 95% confidence intervals,0.927-1.470, p = 0.189 for DD, and 1.085, 95% confidence intervals, 0.875-1.345 p = 0.460 for II).Conclusion: Our results suggest that the presence of the D allele may confer protection against the development of VTE in an ethnically Chinese population in Taiwan. Further meta-analysis did not support a relationship between
the ACE I/D polymorphism and the risk of VTE.