近年來癌症化學治療藥物日新月異，但是順鉑(cisplatin) 與其相關鉑金類藥在化學治療物中卻依然為不可替代藥物之一。順鉑於臨床使用上最為顯著的副作用：急性腎損傷，一直是臨床醫師想要克服之處。不論是投予藥物前給予大量點滴或是藥物，在臨床上依然無法完全避免腎臟功能受到影響。因此急性腎損傷生物標記的最新發現似乎提供給臨床醫師一個早期診斷、更早介入治療，可爭取更長的有效治療時間。本文回顧近年文獻關於順鉑造成急性腎損傷的機轉、治療與最新沿革，盼能提供臨床醫師對於順鉑造成急性腎損傷有更進一步了解。

Cisplatin and platinum related medication are mainly use in treating head and neck cancer, esophageal cancer, genital cancer(including testis and ovarian cancer), cervical cancer and non small cell lung cancer.Cisplatin induced acute kidney injury is the major concern for clinicians prescribing cisplatin based chemotherapy regimen. Many years, researchers and clinicians did lots of efforts toget rid of cisplatin side effects. The ways preventing cisplatin induced kidney injury include large intravenous fluid and mannitol. But there are more and more studies revealing that even with these managements, around one third of patients receiving cisplatin based chemotherapy suffered with acute kidney injury. Early diagnosis of AKI(acute kidney injury) may help primary
clinicians prevent its further deterioration and related complications,and augment the chance of renal recovery.