尋求良好腸道清淨方法，是內視鏡檢查醫師所追求的目標。本研究主要目的是要探討生大黃膠囊與傳統方法對於腸道清淨效果的比較。隨機將安排大腸內視鏡檢查之病人分爲大黃組（n=63，男/女=34/29）及對照組（n=68，男/女=42/26），大黃組於檢查前一晚服用生大黃膠囊8粒（500毫克/粒），對照組則是於檢查前一晚服用castor oil 30毫昇及dulcolax 3粒（5毫克/粒），隨後兩組皆服2000毫升開水。檢查結果發現大黃組之腸道清淨效果比對照組爲佳，完全清淨者(Grade Ⅰ)大黃組優於對組(20.7% vs 7.4%，p<0.001)。在可接受檢查程度者(Grade Ⅰ~Ⅲ)，大黃組與對照組分別爲92.1%及82.4%。兩組藥物在清腸方法之副作用主要爲腹絞痛及惡心，但兩組無統計學上之差異。由本研究結果得知大黃膠囊用於腸道清淨有以下之特點：(1)排便次較少，平均2~3次，且較無劇瀉及嚴重腹絞痛。(2)右側大腸及迴盲部排空效果優於對照組。(3)腸腔內較無氣泡及糞水存在。因此本研究之結論認爲服用生大黃膠囊在大腸內視鏡腸道清淨是一種簡單有效之方法。

Searching for a good colon cleansing method is the aim of all endoscopist. The purpose of this study is to compare the efficacy of colon preparation in the rhubarb group with control group. Consecutive patients was randomized into rhubarb group (n=63, M/F=34/29) and control group (n=68, M/F=42/26). 8 capsules were oral intake at the previous night of examination in rhubarb group and castor oil 30ml plus dulcolax 3 tablets were oral intake at previous night of examination in control group. At least 2000m1 of water were taken in both groups. The result of the colonoscopic examination shows that rhubarb group has the superior effect of colon cleansing than control group. In the complete cleansing grade (Grade Ⅰ), the rhubarb group is significant better than control group (20.7% vs 7.4%, p<0.00l) In the fair cleansing grade(GradeⅠ~Ⅲ) of the rhubarb group and the control group is 92.1% and 82.4%, respectively . Abdominal cramping and nausea are the main symptoms of the side effect. But there is no significant differency in both groups. We got the features of rhubarb capsule from the result of this study includes the following: (1)only 2~3times of stool passage, no severe diarrhea and severe cramping. (2)emptying response is better than the control group over right side colon and ileocecal area. (3)scanty air bulbs and no fecal fluid remain in the lumen of colon. Therefore, the conclusion of this study is that oral intake rhubarb capsule is a simple and effective method in colon cleansing of colonoscopy.