神經性膀胱患者經常發生反覆性泌尿道感染，對於這類患者並不建議使用預防性抗生素，因此泌尿道感染預防的替代療法有其必要性，蔓越莓就是其中最常見的方法之一，但是其效果尚未有一致的定論。本研究的主要目的是探討蔓越莓再加上維他命C的使用，是否能降低神經性膀胱患者菌尿症以及膿尿症的發生。本研究參與者爲10位住院以及18位門診之神經性膀胱患者，被隨機分到3組：蔓越莓組、蔓越莓加維他命C組、對照組。參與者每日服用本實驗製劑兩次。住院患者服用4週，門診患者服用6個月。主要測量項目爲菌尿或膿尿的改善程度，住院患者每週利量尿液一次，追蹤期一個月；門診患者每月測量尿液一次，共追蹤6次。結果顯示住院及門診受試者不論是蔓越莓組、蔓越莓加維他命C組、或對照組的膿尿與菌尿的改善程度，彼此間並無統計上差異。本篇研究的主要限制爲受試人數過少，無法確定蔓越并加上維他命C在預防或改善神經性膀胱患者膿尿與菌尿上的功效，未來仍需大規模及長期的研究。

The patients with neurogenic bladder arc susceptible to repeated urinary tract infection. It is not recommended for them to take prophylactic antibiotics. Therefore, it is mandatory to find alternatives for the purpose of prevention. Cranberry is the one of the most common ways. However, the effectiveness of cranberry is not well-approved in the literature. The purpose of this study is to investigate whether bacteriuria and pyuria can be prevented with combination of cranberry and vitamin C in the patients with neurogenic bladder.10 inpatients and 18 outpatients with neurogenic bladder were randomly allocated into 3 groups: cranberry, combination of cranberry and vitamin C, and control group. All participants took medicine or placebo twice per day for 4 weeks with inpatients and for 6 months with outpatients. Bacteriuria and pyuria were assessed before treatment and at weekly interval for inpatients and at each monthly follow-up visit for outpatients.There were no significant differences on the degree of improvement on bacteriuria or pyuria in cranberry, combination of cranberry with vitamin C, and control group. Because current sample size is limited, we could not confirm the effects of cranberry combined with vitamin C on the improvement of pyuria or bacteria in neurogenic bladder patients. Further studies with larger sample sizes and longer follow-up periods are warranted to confirm our results.