57歲男性病患，為慢性B型肝炎合併肝硬化，五年內使用拉美芙錠治療共計三個療程，第一療程於停藥後2個月，第二療程於停藥後9個月，肝炎急性發作。患者於2003-12-15接受拉美芙錠第三療程治療，因擔心停藥後再次復發，故於2004-8-3至本院中醫科門診，希望配合中藥治療。2005-6-19起病人停用拉美芙錠，並持續服用中藥治療，至今肝炎未再急性發作。在中西結合治療期間，病人血清HBV-DNA<0.5pg/mL，HsAg轉陰，肝功能呈現正常。本病例中西結合治療的經驗，中藥能預防拉美芙錠誘導慢性B型肝炎急性發作，值得進一步研究其機理。

The present case is a male 57 years old with chronic hepatitis B complicated cirrhrosis of the liver. He accepted three courses treatment of lamivudine at within 5 years. The first and second course he suffered from hepatitis B acute exacerbation after closed lamivudine administration for 2 months and for 9 months respectively. The patient administrated the 3rd course of lamivudine treatment since Dec.15 in 2003. He worried the same condition attach again, so he came our hospital expected Chinese Medicinal combined treatment at Aug 8 in 2004. He was persisted lamivudine integrated Chinese herbs treatment until June 19 in 2005. During the period of treatment, the patient's HBV-DNA<0.5pg/mL, HBsAg seroconversion, and the liver function test were present normal values. The case didn't suffer from the 3rd acute exacerbation at our OPD followed. It suggests that Chinese Medicinal can prevent lamivudine induced acute exacerbation of chronic hepatitis B and worthy further research of mechanism.