Primary lymphomas of the liver are a very rare malignancy. Most often, these lesions consist of a diffuse large B-cell non-Hodgkin's lymphoma that occurs mostly in immunodeficient patients. To prove the primary nature of a hepatic lesion, a systemic lymphoproliferative disease or metastasis from another solid cancer must be ruled out. We report the first case diagnosed as having a primary hepatic diffuse large B-cell lymphoma in a patient who had undergone a handassisted radical nephrectomy for left renal cell carcinoma (RCC) 5 years 7 months earlier