研究目的：儘管對於前列腺肥大，臨床上已有許多方法被發展出來，但是最理想的治療方法仍有待確認。我們針對以經尿道前列腺內酒精注射法進行研究，將初步獲得之臨床經驗作一報告。材料與方法：自西元2003年12月至2004年4月間，本院共有22名前列腺肥大症之病患參與此一研究，平均年齡為72.8歲。絕對酒精以內視鏡的方式，經由尿道分別注射在前列腺二處或以上的部位，劑量在3亳升至30毫升之問（平均9.9毫升）。結果：所有病人均無術中併發症。術後有4名病人 (18.2%) 發生急性尿滯留，平均住院天數2.7天。前列腺平均大小從術前的51.6公克降至術後3個月的29.7公克 (P=0.001)；平均國際前列腺症狀積分(IPSS)則從26.1分降至20.7分（術後3個月）(P=0.022)；平均最高尿流速從9.8毫升／秒增加至14.8毫升／秒（術後3個月）(P=0.035)。在第6個月門診追蹤時，這些數值就不再出現有意義的變化。病理切片報告顯示所有病人均無惡性變化。最常見的併發症依序為頻尿 (21/22)、暫時性解尿困難 (19/21)以及急性尿滯留 (4/22)。結論：我們的初步臨床經驗顯示，這項技術可在極短的住院天數下甚至以門診治療的形態被施行。當病人日常生活為前列腺阻塞症狀所影響時，此法可被考慮，尤其可用於不適合長時問麻醉的高危險族群。值得注意的是，酒精注射所引發類似前列腺發炎的頻尿症狀，會替病人及臨床醫師帶來很大困擾，如何有效控制此一問題，是術後照顧上的一大挑戰。

OBJECTIVES: Despite extensive research involving numerous treatments for benign prostatic hyperplasia (BPH), the ideal modality has yet to be determined. We clinically evaluated chemoablation of the prostate using a transurethral intraprostatic absolute ethanol injection (AEI).MATERIALS AND METHODS: Dehydrated ethanol was injected transurethrally into 22 patients with prostatic obstruction. The mean patient age was 72.8 ± 9.0 (median, 20.0) years. Injections were performed under cystoscopic surveillance at bilateral sites of the prostate for an overall amount of 3~30 (mean, 9.9 ± 6.9; median, 6.0) ml of ethanol for each patient.RESULTS: There were no intraoperative complications, but postoperative urinary retention occurred in 4 patient (18.2%). The mean hospital stay was 2.7 ± 2.9 (median, 2.0) days. The mean prostate volume decreased from 51.6 ± 22.3 (median, 50.3) to 29.7 ± 16.9 (median 25.6) g at 3 months postoperatively (p=0.001; paired-sample t-test). The mean IPSS score decreased from 26.1 ± 4.2 (median, 26) to 20.7 ± 5.2 (median, 20.0) at 3 months postoperatively (p=0.022; paired-sample t-test); the mean peak urine flow rate increased from 9.8 ± 5.4 (median, 9.0) to 14.8 ± 6.0 (median, 15) ml/s at 3 months postoperatively (p=0.035; paired-sample t-test). There were no significant differences at 6 months when the same parameters were assessed. Pathological findings for all patients showed no evidence of malignancy in the treated area. Conditions for which the most patients complained about were frequency (21/22), transient difficult micturition (19/22), and acute urinary retention (4/22).CONCLUSIONS: Our initial results suggest that this technique can be performed with a short hospital stay or as an outpatient procedure. It can be considered another treatment choice for prostatic obstruction due to benign hyperplasia, especially when a patient is at high risk. Controlling the postoperative frequency of alcohol-induced prostatitis is still a problem we cannot ignore.