背景：在接受經尿道攝護腺切除手術 (TURP) 之年老男性病患中，偶有急性痛風性關節炎發生的情形，這項併發症會造成住院天數延長並增加醫療費用，在本文之中我們探討了接受TURP後痛風發作之機會及血清尿酸濃度之變化，並嘗試釐清兩者之關係。方法：從西元2002年至2003年之間，隨機挑選了52個在國軍桃園總醫院接受TURP的病患納入本研究，在行TURP術前及術後皆有抽血檢驗尿酸濃度。此外有12個病人還同時檢驗血清中的鈉及尿液中尿酸濃度。結果：這些病人血清中的平均尿酸濃度從術前的5.929±1.776升至術後2個小時的6.169±1.687(p<0.05)，術後24小時的血清尿酸濃度 (5.706 ± 1.514和術後48小時的濃度(5.263±1.585)兩者與術前比較則有顯著下降 (p<0.05)，而血清中的鈉離子濃度從術前139.99±1.83降到術後的137.25 ± 2.87(p>0.05)，術後有兩個病人有急性痛風發作，且血清尿酸濃度也有下降的趨勢。結論：血清中的尿酸濃度低於TURP手術後明顯降低，52個病人中有兩位有術後急性痛風性關節炎的發作。但尿酸濃度的改變與痛風是否發作並無確定的關聯，這需要更進一步術前及術後血液中及關節液中尿酸濃度的檢驗作深入探討。

OBJECTIVE: An acute gout arthritis attack is occasionally found in elderly men with benign prostatic hyperplasia (BPH) who have received transurethral resection of the prostate (TURP). It may increase the length of stay in the hospital and increase medical costs. In this study, we evaluated the incidence of acute gouty arthritis and serum uric acid changes in patients who received TURP, and attempted to elucidate their relationships.MATERIALS AND METHODS: From January 2002 to June 2003, fifty-two patients who receive TURP at the Armed Forces Taoyuan General Hospital were enrolled in this random study. Blood samplings were taken for serum uric acid level before and after TURP, respectively. In addition, serum sodium and the uric acid level in the urine were checked in 12 patients before and after the operation as well.RESULTS: These patients had an average preoperative level of uric acid which rose from 5.929±1.776 mg/dL to an immediate postoperative average of 6.169 ± 1.687 mg/dL (p＜0.05). There was a significant decrease in the serum uric acid concentration 24 hours postoperatively (5.706±1.514 mg/dL, p＜0.05) and a further decrease 48 hours postoperatively compared to the preoperative concentration (5.263 ± 1.585 mg/dL, p＜0.05). The average serum sodium level dropped from 139.99±1.83 mmol/L preoperatively to 137.25±2.87mmol/L postoperatively (p＞0.05). Two patients experienced an acute gout attack after TURP, and their uric acid levels dropped slightly more than the uric acid level of those who did not experience a gout attack.CONCLUSIONS: The serum uric acid level significantly dropped after TURP. Two of our 52 patients did suffer from acute gouty arthritis postoperatively. But there seemed to be no definite relationships between the serum uric acid level changes and the acute gout attack after TURP. Further study of the uric acid level changes in blood and joint synovial fluid before and after the operation is recommended.