篇名 | Prostatic Pure Small Cell Carcinoma v.s. Mixed-Type Small Cell Carcinoma: Analysis of Two Cases |
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卷期 | 16:3 |
並列篇名 | 單純型及混合型前列腺小細胞癌之兩病例分析 |
作者 | 許智凱 、 鄭建睿 、 陳冠州 、 江漢聲 、 朱娟秀 |
頁次 | 115-118 |
關鍵字 | Prostate 、 Small cell carcinoma 、 Neuroendocrine 、 Immunohistochemical studies 、 攝護腺 、 小細胞癌 、 神經內分泌 、 組織免疫染色 |
出刊日期 | 200509 |
前列腺小細胞癌爲少見的前列腺惡性腫瘤.我們整理分析近年來本院的兩個病例。第一位病人爲單一細胞型態的單純小細胞癌,診斷時已合併多重器官之轉移,第二位病人則是混合型的小細胞癌。兩病例病理切片組織免疫特殊染色皆呈現chromogranin A,synaptophysin,and cytokeratins陽性,及陰性的PSA染色。第一例在經尿道前列腺切除手術做出診斷後給予gemcitabine及carboplatin的複合性化學治療及放射治療,其骨骼轉移病灶得到部分改善。第二例則是在姑息性經尿道前列腺切除手術後給予體外放射線治療。
We analyzed 2 cases of small cell carcinoma of the prostate. One patient had pure small cell carcinoma with multiple organ metastasis, while the other had a mixed-type carcinoma. The immunohistochemical studies revealed positive reactions to chromogranin A, synaptophysin, and cytokeratin stains, and negative for PSA stain over both small cell carcinoma foci. These 2 patients were immediately treated, and partial resolution of the previous metastatic bone lesions was noted after receiving 5 courses of chemotherapy with the combination of gemcitabine, carboplatin, and irradiation therapy in case 1, while adjuvant irradiation was scheduled for case 2.