隨著大氣壓力質譜法 (ambient mass spectrometry) 的快速發展，使得質譜儀可以直接在大氣壓力環境且不需樣品前處理的條件下進行快速的化學成分分析。以電噴灑游離法 (electrospray ionization, ESI) 與大氣壓力化學游離法 (atmospheric pressure chemical ionization, APCI) 為基礎，至目前為止，已有 60 種以上的
游離技術相繼被開發且應用在各種不同領域的快速檢測。本文主要介紹一新式的熱脫附電噴灑游離技術(thermal desorption electrospray ionization, TD-ESI) 之原理與操作。該檢測方法結合熱脫附技術與後游離技術，具有許多優勢，包含樣品可不需要任何前處理、分析時間短、操作容易且能快速偵測大量樣品，從取樣至獲得質譜訊號不到 5 秒鐘，適用有時效性之快速篩檢。本文亦將列舉該技術於食品安全、農藥殘留、毒品檢測與藥物濫用之應用。

In past few years, ambient ionization sources, which has witnessed a flurry of developments, is a set of useful techniques for the analysis of samples under open-air conditions. The state-of-the-art of the technique allows direct, rapid, real-time, and high-throughput analyses with little or no sample pretreatment. It also provides the analyses of a wide range of substances from various surfaces and matrices. In the study, we describe a novel ionization method for rapid chemical analysis. This so-called thermal desorption electrospray ionization (TD-ESI) combines thermal desorption of sample analytes from solids or liquids and post ionization via electrospray. Basically, TDESI technique involves three independent steps: sampling, desorption, and ionization. As equipped with a mass spectrometer, it is quite suitable for the direct, rapid, real-time and in-situ analysis. Here, we report the principle, operation and also its wide range of applications including food safety, pesticide, residue, forensic science, and drug abuse.