目的：針對接受放射治療的肝癌患者，進行營養與生活品質評估，並探討放射治療與營養狀況對其生活品質的影響。材料與方法；自2007年8月至2009年6月，以中部某醫院接受放射治療的150名肝癌病患為研究對象。藉由簡易營養評估量表及歐洲癌症治療與研究組織生活品質問卷，評估病患在放射治療前、治療結束和治療結束後1個月之營養狀況與生活品質。結果：42%病患於放射治療前有營養問題，且接受放射治療前後之營養狀況未達顯著差異（Friedman X^2=2.06，P=0.358）。無論放射治療前、放射治療結束時和放射治療後1個月之營養狀況與當時之「整體生活晶質及健康狀況」、所有「功能性尺度」及多數的「症狀尺度／單項」均達到顯著相關。使用廣義估計方程式發現，「整體生活品質及健康狀況」（P<0.01）、「整體生活品質功能狀態」（P<0.05）、五種最嚴重症狀尺度中包括「疲倦」（P<0.05）、「經濟困難」（p<0.001）與「疼痛」（p<0.01）於放射治療後均有顯著改善。營養狀況與「整體生活品質及健康狀況」（P<0.001）、「整體生活品質功能狀態」（P<0.001）、「失眠」（P<0.01）、「疲倦」(P<0.001)、「經濟困難」(P<0.001)、「食慾不振」(p<0.001)與「疼痛」（P<0.001）都有顯著關係。結論：雖然放射治療短期未能改善病患的營養狀況，但有助於改善病患的生活品質與多數主要症狀。病患的營養狀況直接影響其生活品質與主要症狀。因此，肝癌患者於放射治療前應進行營養狀態評估與早期營養照護的介入，可使其生活品質變得改善。

Purpose: The aims of this study are assessing the nutritional status and quality of life (QoL) in the patients with hepatocellular carcinoma treated by radiotherapy, and discussing the impacts of radiotherapy and nutritional status on QoL. Materails and Methods: From August 2007 to April 2009, one hundred and fifty hepatocellular carcinoma patients treated by radiotherapy at a teaching hospital in central Taiwan were enrolled in this study. Nutritional status and QoL of the patients were assessed by means of the Mini-Nutrition Assessment (MNA) and European Organization for Research and Treatment of Cancer Quality of Life Core-3D (EORTC QLQ-C30) at three different time points: before treatment, end of treatment, and 1 month after treatment. Results: Forty-two percent patients had the problem of nutritional status before radiotherapy. There was no significant changes in nutritional status of the patient s who received radiotheray (Friedman X^2 = 2.06, p = 0.358). The nutritional status correlated with global health status, all five functioning scales and the most of symptom scales /item at all of the different time points. Using generalized estimating equation, global health status (p < 0.01), global functioning status (p < 0.05), the most severe symptoms included fatigue (p < 0.05), financial difficulty (p < 0.001 ), and pain ( p < 0.01) were significantly improved after radiotherapy. The nutritional status o f the patients were strong relationship with global health status (p < 0.001), global functioning status (p < 0.001), insomnia (p < 0.01), fatigue (p < 0.001), financial difficulty (p < 0.001), loss of appetite (p < 0.001) and pain (p < 0.01). Conclusion: Although the level o f nutritional status of the patients is not effectively increase in a short period, it would be worth to note that the QoL and the most of the major symptoms are significantly improved after the patient s received radiotherapy. Considering, the nutritional status of the patients will directly influence their QoL and the major symptoms. The patients with hepatocellular carcinoma should have to establish nutritional assessment and arrange early nutritional intervention before radiotherapy to get more nutritional support, and in turn to improve the QoL.