目標：壬基苯酚(nonylphenol, NP)是一種廣流布在環境中的內分泌干擾物，人體暴露深受
關切。本研究以橫斷式研究探究不孕治療之夫婦的飲食和生活習慣與尿液壬基苯酚暴露的相
關。方法：經由婦產科對53對就診夫婦進行調查，每名應允參加者均填答一份問卷提供人口、
社經、生活與飲食習慣等資料，41位男士和49位女士提供了尿樣。結果：男士年齡較大，身體
質量指數較大，也較多抽菸和飲酒，但尿樣的壬基苯酚含量平均值並無男女差別(分別為1.26±
0.39對1.28±0.31 µg/g creatinine，p = .821; Pearson correlation相關係數 r= .31, p= .012)。比較所有
人口，社經及生活型態、食物變項，只發現多服食保健食品者的含量明顯高(1.35±0.34對1.16±
0.34 µg/g creatinine) (p = .012)。多喝高脂奶者亦有較高的含量，但不顯著。結論：此為首次以
共同生活的夫婦樣本為對象，討論生活飲食習慣與人體壬基苯酚暴露濃度的關聯的論文，男性
與女性的尿液壬基苯酚含量無顯著差別，多服食保健食品者的尿液壬基苯酚含量較高，其餘生
活飲食習慣與尿液壬基苯酚含量無明顯關聯。(台灣衛誌 2012；31(5)：425-434)

Objectives: Nonylphenol (NP) is an endocrine disrupter with wide distribution in the
environment, particularly in foodstuffs and polluted water. Human exposure to NP has been
of concern. This study evaluated the NP levels in couples with infertility, by using urinary
4-nonylphenol (4-NP) as a biomarker. Methods: Subjects were 53 married couples who were
visiting the obstetrics and gynecology clinic. Of these, 41 men and 49 women provided urine
samples. Each participant also completed a self-reported questionnaire to provide information
about sociodemographic status and life style including diet. Results: Men were older, had a
higher body mass index and were more likely to smoke, drink and use betel nut; however, the
mean urinary NP levels were similar in men and women, 1.26 (SD 0.39) vs. 1.28 (SD 0.31) µg/g
creatinine (p= .821; Pearson correlation r= .31, p= .012). Among all measured sociodemographic
and life style factors, only those individuals who had consumed more healthy food had
significantly higher urinary NP levels than did subjects who had consumed less or did not
consume healthy food at all. (1.35 (SD 0.34) vs. 1.16 (SD 0.34)) µg/g creatinine (p= .012). Those
who consumed more whole milk also had higher mean urinary NP levels, but this fnding was not
statistically signifcant. Conclusions: Our fndings demonstrated that married couples had similar
exposure to NP from the consumption of foodstuffs. Eating healthy food was associated with
higher urinary nonylphenol levels. Other eating habits showed no signifcant correlation. (Taiwan
J Public Health. 2012;31(5):425-434)