Acne vulgaris is one of the most common dermatological disorders that afflict people in their adolescence. Although it is not life-threatening, severe acne can greatly burden a patient’s psychological status, thereby reduces their participation in social activities. The present review focuses on a pathogenic bacterium, Propionibacterium acnes, in the human skin and summarizes the therapeutic modalities of acne vulgaris, including the pharmaceutical dosage forms of oral and topical administrations. Furthermore, this paper also reviews state-of-the-art in particle-based drug delivery systems and light-based therapy for acne treatment from in vitro and in vivo studies.