C型肝炎病毒感染一直是全球公共衛生上的重要課題。慢性C型肝炎的治療在近年來已
經有了長足的進步，亞太地區在這個研究領域上也有許多深入的研究與新的發現。本文針對
這個主題，首先就全球慢性C肝病毒感染的現況做概述。其次對全球慢性C肝治療方式的演
進作介紹，以及目前依據不同C肝病毒基因型與病毒動力學所建立的個人化治療作解說。最
後並針對未來C肝治療的可能發展方向作介紹。

Hepatitis C virus infection is a global health problem. There is tremendous advancements in the treatment
of chronic hepatitis C in the past two decades. Many new knowledgement in this research area and important
treatment strategies are actually discovered by experts from the Asia-Pacific regions including Taiwan. In this
review, we will briefly review the epidemiology of hepatitis C virus infection, current standard-of-care for patients
with chronic hepatitis C, the role of hepatitis C viral genotype and on-treatment viral kinetics in the individualization
of therapy. Finally we will introduce new direct-acting anti-viral-based triple therapy for patients with hepatitis C
virus genotype 1 infection. (J Intern Med Taiwan 2012; 23: 383-391)