由於乳癌放射治療會因為不同個體的乳房組織與體表輪廓差異性較大，導致不良反應，所以提高腫瘤的控制率，降低周圍正常組織因放射線治療所引起的不良反應是多種不同治療技術發展的最終目的。本研究藉比較混和型強度調控放射治療（Hybrid IMRT）技術與單純強度調控治療技術對於治療乳癌病患在不同區域的劑量分布差異找出最佳化的治療方式。收集20 位因乳癌而接受乳房保留手術合併放射治療的病患，以混和型強度調控與強度調控兩種放射治療方式，需要評估同側肺臟V20 體積與心臟V30 體積，以及評估對側乳房V5 體積。研究結果顯示，Hybrid IMRT與IMRT的腫瘤體積包覆性及均勻性相似，同側肺臟低劑量V5體積的比較為40.86% vs. 64.78%（P value<0.05）、肺臟V10 體積的比較為26.73% vs. 34.93%（P value<0.05）；肺臟V20 體積及肺臟V30 體積中所接受到的劑量體積並無明顯增加；心臟V5 體積的比較為30.46% vs. 73.18%（P value<0.05），心臟V10 體積為13.79% vs. 28.75%（P value<0.05），但在V20 體積與 V30 體積的結果並無明顯增加。對側乳腺V5 體積為6.24%vs. 17.32%（P value < 0.05），IMRT 對於對側正常乳腺有較高的低劑量影響。
IMRT 對乳癌放射治療的主要目標是減少劑量的不均勻性，並降低皮膚反應，減少慢性皮膚變化和纖維化；亦能降低正常組織和器官的照射風險，如心臟以及同側肺臟，可使急性和晚期副作用下降。兩種治療方式在治療規劃及治療時間上無太大差異，Hybrid IMRT 可改善傳統切線放射治療所造成的劑量不均勻，同時能避免造成肺臟及心臟接受到較多低劑量體積；目前本科已將Hybrid IMRT 普遍應用於乳癌的臨床治療上。

There will be side effects of breast cancer radiation therapy due to different individuals of the breast tissue and body surface contour. Therefore, the purpose of the development of different treatment techniques was improve tumor control rate and reduce the adverse reactions caused by the surrounding normal tissue due to radiation therapy. In this study, we wanted to find out that the optimized treatment technique by comparing Hybrid IMRT technology and IMRT techniques for patient with breast cancer in different regions of the dose distribution. Evaluation the volume of the ipsilateral lung V20, heart the V30 volume, and contralateral breast V5 volume in 20 patients of breast cancer with conservation and IMRT or hybrid IMRT. Target coverage and homogeneity were similar. For hybrid IMRT, 40.8% of the ipsilateral lung received a dose of ≥5 Gy (V5) and 26.73 % a dose of≥10 Gy (V10). V5 and V10 were found to be 64.78% and 34.93% for IMRT, respectively. For hybrid IMRT, 30.46% of the heart received a dose of ≥5 Gy (V5) and 13.79 % a dose of≥10 Gy (V10). V5 and V10 were found to be 73.18% and 28.75% for IMRT, respectively. The contralateral had higher low-dose effect in IMRT. Target coverage and homogeneity were similar. For hybrid IMRT, 40.8% of the ipsilateral lung received a dose of ≥5 Gy (V5) and 26.73 % a dose of≥10 Gy (V10). V5 and V10 were found to be 64.78% and 34.93% for IMRT, respectively. For hybrid IMRT, 30.46% of the heart received a dose of ≥5 Gy (V5) and 13.79 % a dose of≥10 Gy (V10). V5 and V10 were found to be 73.18% and 28.75% for IMRT, respectively. The contralateral had higher low-dose effect in IMRT.