Abstract. Datagram congestion control protocol (DCCP) is a transport-layer protocol designing for multimedia applications to transmit congestion-controlled data streams over Internet. The major features of DCCP protocol include a TCP-friendly rate control (TFRC) mechanism to ensure fair bandwidth sharing with TCP, and a partial payload protection mechanism to retrieve the effective data from error-corrupted packets. In enabling a robust data transmission for DCCP flows over wireless networks with the automatic repeat request (ARQ) capacity, the packetization scheme needs to be fitted to the new DCCP features and ARQ-based transmission scenario. To be more specific, the partial payload protection mechanism can be inefficient owing to MAC-layer retransmissions, while varying packet size has an adverse effect on the TCP-friendliness of DCCP flows. This paper proposes two main contributions in designing the efficient packetization scheme for DCCP flows, namely (1) a DCCP protocol enhancement to benefit the partial payload protection mechanism by utilizing the ARQ retransmissions and then (2) an in-packet segmentation scheme to improve the data goodput while preserving the TCP-friendliness of the DCCP flows. The experimental results demonstrate the effectiveness of the proposed scheme based on the results of packet corruption probability and normalized throughput under a variety of network conditions.