Colonoscopy that is a very commonly carried out procedure has several problems, including a risk of perforation of the colon and significant discomfort for patients. Loop formation can be the reason of these problems. Loop formation is further associated with the configuration of the colon, in particular the rectum-sigmoid and sigmoid-descending segments that have a small curvature and “S”-shaped profiles where the looped colonoscope exerts a quasi-static force on intestinal wall, and then results in deformation of the intestinal wall. Variable-stiffness colonoscope and over-tube colonoscope may be used to prevent loop formation; however, conflicting results relating to their use have been reported. In this paper, influence of a looped colonoscope on deformation of the intestinal wall is analyzed. It was found that the flexural rigidity of the looped colonoscope contributes deformation of the intestinal wall.