篇名 | Direct Renin Inhibitor Attenuates Left Ventricular Remodeling in Post-Myocardial Infarction Heart Failure Mice |
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卷期 | 29:2 |
作者 | Ning-I Yang 、 Chia-Chi Liao 、 Ming-Jui Hung 、 Wen-Jin Cherng |
頁次 | 160-167 |
關鍵字 | Direct renin inhibitor 、 Echocardiography 、 Heart failure 、 MEDLINE 、 SCI 、 Scopus |
出刊日期 | 201303 |
Background: The role of direct renin inhibitors in myocardial ischemia-induced heart failure is controversial. We hypothesized that direct renin inhibitors play a positive role, affecting in vivomyocardial function as well as in vitro extracellular matrix change.
Methods: Ten-week-old C57BL/6J male mice with 2-kidney 1-clip (2K1C) model were enrolled in this study. The mice were divided into 3 groups each with 18 mice; group 1 sham-operated, group 2 coronary artery ligationinduced heart failure, and group 3 coronary artery ligation-induced heart failure receiving aliskiren minipump infusion. These mice were assessed for systemic hemodynamics and left ventricular function by 2-dimensional echocardiography (iE33, Philips). Myocardial tissue was stained and crude protein was isolated from the nonischemic viable left ventricle. Myocardial tissue contents of anti-angiotensin II type 1 (AT1) receptor, matrix metalloproteinase (MMP)-2 and MMP-9 were examined.
Results: There were 54 mice that received 2K1C and were followed up for three weeks. Baseline characteristics showed no difference. At follow-up, the heart failure-only group had greater left ventricular mass and worse systolic function as compared to the sham group. Whereas the heart failure-aliskiren group had lower left ventricle mass and better systolic function as compared to the heart failure-only group. AT1 receptor, MMP-2 and MMP-9 levels were increased in the heart failure-only model while direct renin inhibitor attenuated this significantly.
Conclusions: Direct renin inhibitors improved myocardial function in a myocardial ischemia-induced heart failure mouse model. The improvement seen is present in myocardial mass, left ventricular systolic function and also in myocardial interstitial tissue.