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內科學誌 Scopus

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篇名 非懷孕成人B型鏈球菌感染的死亡因素分析
卷期 24:2
並列篇名 Risk Factors for Mortality in Non-pregnant Adults with Group B Streptococcus Bacteremia
作者 陳昶華張家築
頁次 131-136
關鍵字 Clinical presentationsGroup B StreptococcusBacteremiaMortalityPrognostic factorScopusTSCI
出刊日期 201304

中文摘要

本研究分析台灣中部地區的非懷孕成年患者罹患B型鏈球菌菌血症的預後因素。2001年1月1日至2009年12 月31日在研究醫院進行本研究。在研究期間,B型鏈球菌菌血症的發病率分別為每十萬住院病患有24.3例。在63例B型鏈球菌菌血症患者中,26例患者均為男性,平均年齡為57.1歲。最常見的感染源是皮膚和軟組織感染(27,42.9%)。存活組與死亡組在C- 反應蛋白、敗血症的現象有明顯不同(8.8±8.9mg/dL v.s 18.7±6.8 mg/dL,P=0.013;32.6%v.s. 64.1%,P <0.001)。診斷日當天舒張壓在兩組之間差異有統計學差異(81.3±11.8 mmHg vs.63.1±16.5 mmHg,P =0.033)。總病死率為36.9% (17例)。C- 反應蛋白升高和低舒張壓和敗血症的現象是B型鏈球菌菌血症的三項重要死亡因子。

英文摘要

This study analyzed the prognostic factors of Group B streptococcus (GBS) bacteremia in non-pregnant adult patients in Central Taiwan. An observational study was conducted between January 1, 2001 and December 31, 2009 at the study hospital. The overall incidence rate of GBS bacteremia was 24.3 cases per 100,000 admissions during the study period. Among the 63 patients, 26 patients were male with a mean age of 57.1 years. The most common source of infection was skin and soft tissue infection (27, 42.9%). The C-reactive protein (CRP) and sepsis sign were markedly different between the expired and survival groups (8.8 ±8.9 mg/dL vs. 18.7±6.8 mg/dL, p=0.013 and 32.6% v.s. 64.1% , p<0.001), respectively. The diastolic blood pressure on the day of diagnosis had a statistically significant difference between the two groups (81.3±11.8 mmHg vs.63.1±16.5 mmHg, p=0.033). The overall case fatality rate was 36.9% (17 cases). Elevated CRP level, low diastolic blood pressure and sepsis sign were most significant difference at the initial presentation, and were poor prognostic factors for mortality.

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