苗栗縣某一蓋斑鬥魚養殖場，飼養蓋斑鬥魚總數約3,250尾，成魚與幼魚混養，魚隻體長約2-6 cm。於夏季更換飼料後，魚隻體表陸續發現潰瘍且接連死亡，發病率與累積死亡率皆為100% (3，250/3，250)。病魚之外觀可見鰭基部、泄殖孔周邊和腹部兩侧皮下出血、體表潰瘍與腹部腫脹。 剖檢後發現鰓絲蒼白且鰓部黏液增生、腸道水腫、脾腎肝有多發性局部白色結節。組織病理學檢查 發現脾腎肝有多發性肉芽腫。自體表潰瘍灶、脾腎肝之肉芽腫皆可分離出Photobacterium damselae subsp. piscicida和Edwardsiella ictaluri。將上述兩種病菌進行動物接種和藥物敏感性試驗，證實P. damselae subsp. piscicida為強毒菌株且對許多抗生素具敏感性，為本次疫情之主要病原菌，而E. ictaluri為弱毒株，非本次疫情之主要病原菌。因此，由上述觀察診斷結果，建議畜主將發病魚隻 隔離並加強換水，避免過度密飼，並投予10-20 mg/kg/day oxolinic acid連續7天。經上述處理後， 疫情已有改善。

There were about 3,250 paradise fishes, Maclopodus opercukaris Linnaeus, were cultured in the Miaoli County in Taiwan. After feed change in the May, the rotten body surface and contiguous dead of cultured paradise fish were found. The clinic findings of the diseased fishes were bled at basal fins, peripheral site of genital pore and bilateral surface of abdomen. Whitish-mucus gills, edema intestine, and multi-focal white tubercles were discovered at necropsy. From the histopathology study, the results showed multi-focal granulomas in spleen, kidney, and liver. Photobacterium damselae subsp. piscicida and Edwardsiella ictaluri were isolated from above lesions. From the results of the experimental animal tests and antimicrobial susceptibility tests, Photobacterium damselae subsp. piscicida shown more violent than the other. Therefore, it might be this case major pathogen. At the same time, Photobacterium damselae subsp. piscicida was susceptible to many antibiotics. After the culture management enhanced, we suggested that to treat with 10-20 mg/kg/day oxolinic acid for 7 days for the cultured tanks. Finally, this case was significantly improved and controlled after treatment.